IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

被引：1355
作者：
Honda, Kenya
Taniguchi, Tadatsugu
机构：
[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 09期
关键词：
D O I：
10.1038/nri1900
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.
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页码：644 / 658
页数：15
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