Autophagy in Age-Associated Neurodegeneration

被引：90
作者：
Metaxakis, Athanasios [1 ]
Ploumi, Christina [1 ,2 ]
Tavernarakis, Nektarios [1 ,2 ]
机构：
[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion 70013, Crete, Greece
[2] Univ Crete, Fac Med, Dept Basic Sci, Iraklion 70013, Crete, Greece
来源：
CELLS | 2018年 / 7卷 / 05期
基金：
欧洲研究理事会;
关键词：
ageing; Alzheimer's disease; amyotrophic lateral sclerosis; autophagy; Huntington's disease; mitophagy; neurodegeneration; Parkinson's sisease; protein aggregation; treatment;
D O I：
10.3390/cells7050037
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The elimination of abnormal and dysfunctional cellular constituents is an essential prerequisite for nerve cells to maintain their homeostasis and proper function. This is mainly achieved through autophagy, a process that eliminates abnormal and dysfunctional cellular components, including misfolded proteins and damaged organelles. Several studies suggest that age-related decline of autophagy impedes neuronal homeostasis and, subsequently, leads to the progression of neurodegenerative disorders due to the accumulation of toxic protein aggregates in neurons. Here, we discuss the involvement of autophagy perturbation in neurodegeneration and present evidence indicating that upregulation of autophagy holds potential for the development of therapeutic interventions towards confronting neurodegenerative diseases in humans.
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页数：24
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