Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation in rats

被引：11

作者：

Fievez, Laurence ^{[1
]}

Kirschvink, Nathalie ^{[1
]}

Zhang, Wenhui H. ^{[2
]}

Lagente, Vincent ^{[3
]}

Lekeux, Pierre ^{[1
]}

Bureau, Fabrice ^{[1
]}

Gustin, Pascal ^{[1
]}

机构：

[1] Univ Liege, Fac Vet Med, Dept Funct Sci B41, Sect Pharmacol Pharmacotherapy & Toxicol, B-4000 Liege, Belgium

[2] Jiao Tong Univ, Dept Physiol, Shanghai 200030, Peoples R China

[3] Univ Rennes 1, INSERM, U620, F-35014 Rennes, France

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 606卷 / 1-3期

关键词：

Cadmium; Emphysema; Glucocorticoid; MMP; Inflammation; OBSTRUCTIVE PULMONARY-DISEASE; SMOKE-INDUCED EMPHYSEMA; TISSUE INHIBITOR; INDUCED SPUTUM; MATRIX-METALLOPROTEINASE-9; METALLOPROTEINASE-1; ASTHMA; GLUCOCORTICOIDS; MODULATION; ELASTASE;

D O I：

10.1016/j.ejphar.2009.01.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cadmium (Cd) induces centrilobular emphysema and is suspected to contribute to tobacco related long diseases as chronic obstructive pulmonary disease (COPD). This study aimed to check whether the inflammatory process observed in Fats exposed to nebulised Cd is resistant to betamethasone as observed in COPD and to determine the influence of this drug on airspace enlargement together with the MMP-2-9/TIMP-1-2 imbalance. Our results showed that betamethasone induced emphysema by itself in healthy rats. Moreover, pre-treatment of rats with betamethasone could only partially modulate the increase in bronchoalvelar lavage fluid cell counts and the absence of preventive effect of this compound against emphysema development is associated with its inability to rebalance the MMP-2-9/TIMP-1-2 ratio. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：210 / 214

页数：5

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