An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality

被引：47

作者：

Marjuki, Henju ^{[1
]}

Mishin, Vasiliy P. ^{[1
]}

Chesnokov, Anton P. ^{[1
,2
]}

De La Cruz, Juan A. ^{[1
,2
]}

Fry, Alicia M. ^{[1
]}

Villanueva, Julie ^{[1
]}

Gubareva, Larisa V. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA

[2] Battelle Mem Inst, Atlanta, GA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 03期

关键词：

H7N9; Fludase (DAS181); oseltamivir; drug resistance; R292K; neuraminidase inhibitor; SIALIDASE FUSION PROTEIN; INFECTION; TAIWAN;

D O I：

10.1093/infdis/jiu105

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported. Here we show that DAS181 (Fludase), an antiviral drug with sialidase activity, potently inhibited replication of wild-type influenza A(H7N9) and its oseltamivir-resistant R292K variants in mice. A once-daily administration initiated early after lethal infection hampered body weight loss and completely protected mice from lethality. We observed a time-dependent effect for 24-72-hour delayed DAS181 treatments on morbidity and mortality. The results warrant further investigation of DAS181 for influenza treatment.

引用

页码：435 / 440

页数：6

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