Evolution of HLA antibody detection - Technology emulating biology

被引：86
作者：
Bray, RA
Nickerson, PW
Kerman, RH
Gebel, HM
机构：
[1] Emory Univ Hosp, Dept Pathol, Atlanta, GA 30322 USA
[2] Univ Manitoba, Fac Med, Winnipeg, MB, Canada
[3] Univ Texas, Sch Med, Dept Surg, Houston, TX USA
来源：
IMMUNOLOGIC RESEARCH | 2004年 / 29卷 / 1-3期
关键词：
transplantation; crossmatch; flow cytometry; alloantibody; HLA;
D O I：
10.1385/IR:29:1-3:041
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
New technological advances in the field of histocompatibility have provided an approach to systematically address the specificity of positive lymphocyte crossmatches. These approaches can now confirm whether a positive crossmatch is (or is not) due to class I and/or class II antibodies directed against donor HLA antigens. The information gained from the application of these sensitive and specific technologies can be used to predict crossmatch results for highly sensitized patients. In summary, these emerging technologies have provided the tools to reliably determine the clinical relevance of a positive lymphocyte crossmatch.
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收藏
页码：41 / 53
页数：13
相关论文
共 38 条
  • [1] A SIMPLE MICRO CYTOTOXICITY TEST
    AMOS, DB
    BASHIR, H
    BOYLE, W
    MACQUEEN, M
    TIILIKAINEN, A
    [J]. TRANSPLANTATION, 1969, 7 (03) : 220 - +
  • [2] LABORATORY AND CLINICAL MANAGEMENT OF THE HIGHLY SENSITIZED ORGAN TRANSPLANT RECIPIENT
    BRAUN, WE
    [J]. HUMAN IMMUNOLOGY, 1989, 26 (04) : 245 - 260
  • [3] Bray R. A., 1998, Human Immunology, V59, P121
  • [4] CHRISTIAANS MH, 1996, TRANSPLANTATION, V15, P1341
  • [5] HLAMatchmaker: A molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A,B amino acid triplet level on kidney transplant survival
    Duquesnoy, RJ
    Takemto, S
    de Lange, P
    Doxiadis, IIN
    Schreuder, GMT
    Persijn, GG
    Claas, FHJ
    [J]. TRANSPLANTATION, 2003, 75 (06) : 884 - 889
  • [6] HLAMatchmaker: A molecularly based algorithm for histocompatibility determination. I. Description of the algorithm
    Duquesnoy, RJ
    [J]. HUMAN IMMUNOLOGY, 2002, 63 (05) : 339 - 352
  • [7] CADAVER RENAL-TRANSPLANT OUTCOME IN RECIPIENTS WITH AUTOLYMPHOCYTOTOXIC ANTIBODIES
    ETTENGER, RB
    JORDAN, SC
    FINE, RN
    [J]. TRANSPLANTATION, 1983, 35 (05) : 429 - 431
  • [8] ANTIGENIC SPECIFICITY OF ANTIBODY REACTIVE IN THE ANTIGLOBULIN-AUGMENTED LYMPHOCYTOTOXICITY TEST
    FULLER, TC
    PHELAN, D
    GEBEL, HM
    RODEY, GE
    [J]. TRANSPLANTATION, 1982, 34 (01) : 24 - 29
  • [9] GAROVOY MR, 1983, TRANSPLANT P, V15, P1939
  • [10] Sensitization and sensitivity - Defining the unsensitized patient
    Gebel, HM
    Bray, RA
    [J]. TRANSPLANTATION, 2000, 69 (07) : 1370 - 1374
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