Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil

被引：16

作者：

Silva, Thaisa C. ^{[1
]}

Tremea, Carolina M. ^{[1
]}

Zara, Ana Laura S. A. ^{[1
]}

Mendonca, Ana Flavia ^{[2
]}

Godoy, Cassia S. M. ^{[2
]}

Costa, Carolina R. ^{[1
]}

Souza, Lucia K. H. ^{[1
]}

Silva, Maria R. R. ^{[1
]}

机构：

[1] Fed Univ Golas, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil

[2] Hosp Trop Dis Dr Anuar Auad, Goiania, Go, Brazil

来源：

MYCOSES | 2017年 / 60卷 / 01期

关键词：

AIDS; histoplasmosis; prevalence; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; DEATH; STATE;

D O I：

10.1111/myc.12551

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory-confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and no--survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non-survivor patients (<. 05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.

引用

页码：59 / 65

页数：7

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