Ionizable calixarene-crown ethers with high selectivity for radium over light alkaline earth metal ions

被引：46
作者：
Chen, XY
Ji, M
Fisher, DR
Wai, CM [1 ]
机构：
[1] Univ Idaho, Dept Chem, Moscow, ID 83844 USA
[2] Pacific NW Lab, Hanford Radioisotopes & Med Sci Program, Richland, WA 99352 USA
来源：
INORGANIC CHEMISTRY | 1999年 / 38卷 / 23期
关键词：
D O I：
10.1021/ic990135+
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two new ionizable calixarene-crown ethers, p-tert-butylcalix[4]arene-crown-6-dicarboxylic acid (3) and p-tert-butylcalix[4]arene-crown-6-dihydroxamic acid (4) with preorganized ionophoric cavities, exhibit high selectivity for Ra-223 over lighter alkaline earth metal ions. The ionizable calixcrowns show promising binding properties for developing a Ra-223-based alpha-emitter radioimmunotherapy.
引用
收藏
页码：5449 / +
页数：5
相关论文
共 41 条
[1]  
[Anonymous], HDB BIOCH MOL BIOL
[2]  
BEKEMISHEV MK, 1994, ANAL CHEM, V66, P3521
[3]  
BOCHI C, 1995, ANAL CHEM, V67, P4234
[4]  
CASE GN, 1990, RADIOACT RADIOCHEM, V58, P60
[5]   SYNTHESIS, COMPLEXATION, AND MEMBRANE-TRANSPORT STUDIES OF 1,3-ALTERNATE CALIX[4]ARENE-CROWN-6 CONFORMERS - A NEW CLASS OF CESIUM SELECTIVE IONOPHORES [J].
CASNATI, A ;
POCHINI, A ;
UNGARO, R ;
UGOZZOLI, F ;
ARNAUD, F ;
FANNI, S ;
SCHWING, MJ ;
EGBERINK, RJM ;
DEJONG, F ;
REINHOUDT, DN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (10) :2767-2777
[6]   COMPARISON OF HIGHLY LIPOPHILIC CROWN ETHER CARBOXYLIC-ACIDS FOR TRANSPORT OF ALKALI-METAL CATIONS FROM AQUEOUS-SOLUTIONS INTO CHLOROFORM [J].
CHAREWICZ, WA ;
HEO, GS ;
BARTSCH, RA .
ANALYTICAL CHEMISTRY, 1982, 54 (12) :2094-2097
[7]   STERIC AND MACROCYCLIC EFFECTS IN THE DISSOCIATION KINETICS OF CYCLIC AND OPEN-CHAIN TETRAAMINE COMPLEXES OF COPPER(II) IN STRONGLY ACIDIC, AQUEOUS-MEDIA [J].
CHEN, LH ;
CHUNG, CS .
INORGANIC CHEMISTRY, 1988, 27 (11) :1880-1883
[8]   Carboxylate-derived calixarenes with high selectivity for actinium-225 [J].
Chen, XY ;
Ji, M ;
Fisher, DR ;
Wai, CM .
CHEMICAL COMMUNICATIONS, 1998, (03) :377-378
[9]   TOWARDS TUMOR IMAGING WITH IN-111 LABELED MACROCYCLE ANTIBODY CONJUGATES [J].
CRAIG, AS ;
HELPS, IM ;
JANKOWSKI, KJ ;
PARKER, D ;
BEELEY, NRA ;
BOYCE, BA ;
EATON, MAW ;
MILLICAN, AT ;
MILLAR, K ;
PHIPPS, A ;
RHIND, SK ;
HARRISON, A ;
WALKER, C .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (12) :794-796
[10]   CAVITANDS - ORGANIC HOSTS WITH ENFORCED CAVITIES [J].
CRAM, DJ .
SCIENCE, 1983, 219 (4589) :1177-1183
12345