Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice

被引：20

作者：

Kondo, Michiyo ^{[1
]}

Nishi, Kosuke ^{[1
]}

Sugahara, Takuya ^{[1
,2
,3
]}

机构：

[1] Ehime Univ, Fac Agr, Matsuyama, Ehime 7908566, Japan

[2] Ehime Univ, Food & Hlth Sci Res Ctr, Matsuyama, Ehime 7908566, Japan

[3] Ehime Univ, South Ehime Fisheries Res Ctr, Ainan, Ehime 7984205, Japan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 14卷

关键词：

Microorganism-fermented tea; Theabrownin; Anti-allergic activity; Mast cell degranulation; RBL-2H3; cells; Mice; PU-ERH TEA; ANAPHYLAXIS; THEABROWNIN; HEALTH; FERMENTATION; ACTIVATION; CHEMISTRY; EXTRACT;

D O I：

10.1016/j.jff.2015.02.045

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ishizuchi dark tea is a microorganism-fermented tea produced in Ehime, Japan. We herein describe the anti-allergic effect of Ishizuchi dark tea. The water extract from Ishizuchi dark tea suppressed degranulation of RBL-2H3 cells in a dose-dependent manner with no apparent cytotoxicity. Fractionation and beta-hexosaminidase release assay of the tea components revealed theabrownins as the major bioactive substance in Ishizuchi dark tea. Phosphorylation of Syk, a tyrosine kinase, tended to be suppressed by treating RBL-2H3 cells with theabrownins. In addition, Ishizuchi dark tea suppressed an allergic symptom in the Cry j1-induced pollinosis model mice. Taken together, these data indicated that Ishizuchi dark tea would be a beneficial functional food with an anti-allergic effect. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：659 / 669

页数：11

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