Molecularly imprinted hollow sphere array for the sensing of proteins

被引：17

作者：

Chen, Wei ^{[1
]}

Xue, Min ^{[1
]}

Shea, Kenneth J. ^{[2
]}

Meng, Zihui ^{[1
]}

Yan, Zequn ^{[1
]}

Wang, Zhe ^{[1
]}

Xue, Fei ^{[1
]}

Qu, Feng ^{[3
]}

机构：

[1] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China

[2] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[3] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China

来源：

JOURNAL OF BIOPHOTONICS | 2015年 / 8卷 / 10期

基金：

美国国家科学基金会;

关键词：

molecularly imprinted polymer; hemoglobin; photonic crystal; naked-eye detection; biosensor; LABEL-FREE DETECTION; PHOTONIC CRYSTAL; COLORIMETRIC DETECTION; FUNCTIONAL MONOMER; CHEMICAL SENSORS; FLUORESCENT DYES; COLLOIDAL ARRAY; IONIC-STRENGTH; BISPHENOL-A; POLYMERS;

D O I：

10.1002/jbio.201400100

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mono-dispersed molecularly imprinted hollow spheres (MIHSs) for hemoglobin (Hb) were prepared by employing silica nanospheres as the sacrificial templates. The obtained hollow spheres with uniform particle size of 360 nm in diameter were characterized by transmission electron microscopy. The outstanding affinities of these MIHSs to the target protein were confirmed by adsorption experiment in aqueous solution. Adsorption equilibrium was achieved within 10 min while the binding capacity (Q(max)) of Hb was 8.84 mu mol g(-1) at pH7.0. Furthermore, the MIHSs were successfully assembled into a closely-packed 3D colloidal array. The molecularly imprinted hollow sphere array (MIHSA) can selectively recognize Hb. As the concentration of Hb increased, the structure color of the MIHSA changed from blue to green, and turn to white finally with maximum red shift for 43nm. The MIHSA showed promising potential for the naked-eye detection of target Hb.

引用

页码：838 / 845

页数：8

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