The anti-bacterial action of diclofenac shown by inhibition of DNA synthesis

被引：124
|
作者：
Dastidar, SG [1 ]
Ganguly, K
Chaudhuri, K
Chakrabarty, AN
机构：
[1] Jadavpur Univ, Div Microbiol, Dept Pharmaceut Technol, Calcutta 700032, W Bengal, India
[2] Indian Inst Chem Biol, Dept Biophys, Calcutta 700032, W Bengal, India
[3] Univ Calcutta, Coll Med, Dept Med Microbiol & Parasitol, Calcutta 700020, W Bengal, India
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 14卷 / 03期
关键词：
non antibiotic; diclofenac sodium; anti-bacterial action; inhibition of DNA synthesis;
D O I：
10.1016/S0924-8579(99)00159-4
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50-100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 mu g Dc per 20 g mouse (Swiss Albino variety) significantly (P < 0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 mu Ci (H-3) deoxythymidine uptake. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码：249 / 251
页数：3
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