The Oscar-worthy role of Myc in apoptosis

被引：98
作者：
Meyer, Natalie [1 ]
Kim, Sam S. [1 ]
Penn, Linda Z. [1 ]
机构：
[1] Univ Toronto, Dept Med Biophys, Div Canc Genom & Proteom, Ontario Canc Inst,Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada
来源：
SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 04期
基金：
加拿大健康研究院;
关键词：
apoptosis; oncogene cooperation; cancer progression; p53; signalling;
D O I：
10.1016/j.semcancer.2006.07.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The discovery that the Myc oncoprotein could drive cells to undergo apoptosis in addition to its well-established role in cellular proliferation came in the early 1990s, at the beginning of a period of explosive research on cell death. Experimental evidence revealed that Myc sensitises cells to a wide range of death stimuli and abrogating this biological activity plays a profound role in tumorigenesis. Our understanding of the molecular mechanism and genetic programme of Myc-induced apoptosis remains shrouded in mystery and the focus of much attention. In this review, we will discuss established data, recent advances and future objectives regarding the regulatory processes and the functional cooperators that effect and abrogate apoptosis induced by Myc. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：275 / 287
页数：13
相关论文
共 178 条
  • [1] THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE
    ADAMS, JM
    HARRIS, AW
    PINKERT, CA
    CORCORAN, LM
    ALEXANDER, WS
    CORY, S
    PALMITER, RD
    BRINSTER, RL
    [J]. NATURE, 1985, 318 (6046) : 533 - 538
  • [2] Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
    Alt, JR
    Greiner, TC
    Cleveland, JL
    Eischen, CM
    [J]. EMBO JOURNAL, 2003, 22 (06) : 1442 - 1450
  • [3] THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX
    AMATI, B
    LITTLEWOOD, TD
    EVAN, GI
    LAND, H
    [J]. EMBO JOURNAL, 1993, 12 (13) : 5083 - 5087
  • [4] Rax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
    Annis, MG
    Dlugosz, PJ
    Cruz-Aguado, JA
    Penn, LZ
    Leber, B
    Andrews, DW
    [J]. EMBO JOURNAL, 2005, 24 (12) : 2096 - 2103
  • [5] ASKEW DS, 1991, ONCOGENE, V6, P1915
  • [6] Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
    Aza-Blanc, P
    Cooper, CL
    Wagner, K
    Batalov, S
    Deveraux, QL
    Cooke, MP
    [J]. MOLECULAR CELL, 2003, 12 (03) : 627 - 637
  • [7] c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
    Bahram, F
    von der Lehr, N
    Cetinkaya, C
    Larsson, LG
    [J]. BLOOD, 2000, 95 (06) : 2104 - 2110
  • [8] p14ARF links the tumour suppressors RB and p53
    Bates, S
    Phillips, AC
    Clark, PA
    Stott, F
    Peters, G
    Ludwig, RL
    Vousden, KH
    [J]. NATURE, 1998, 395 (6698) : 124 - 125
  • [9] Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2F1 loss
    Baudino, TA
    Maclean, KH
    Brennan, J
    Parganas, E
    Yang, CY
    Aslanian, A
    Lees, JA
    Sherr, CJ
    Roussel, MF
    Cleveland, JL
    [J]. MOLECULAR CELL, 2003, 11 (04) : 905 - 914
  • [10] Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster
    Benassayag, C
    Montero, L
    Colombié, N
    Gallant, P
    Cribbs, D
    Morello, D
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (22) : 9897 - 9909
12345678910