Development of Dedicated Brain PET Imaging Devices: Recent Advances and Future Perspectives

被引：70

作者：

Catana, Ciprian ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[2] Harvard Med Sch, Charlestown, MA USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2019年 / 60卷 / 08期

关键词：

PET; neuroimaging; high spatial resolution; multimodal imaging; HIGH-RESOLUTION; 3-DIMENSIONAL RECONSTRUCTION; PERFORMANCE EVALUATION; GLIAL ACTIVATION; DETECTOR BLOCK; DOPAMINE; DESIGN; SYSTEM; INSTRUMENTATION; FEASIBILITY;

D O I：

10.2967/jnumed.118.217901

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Whole-body PET scanners are not optimized for imaging small structures in the human brain. Several PET devices specifically designed for this task have been proposed either for stand-alone operation or as MR-compatible inserts. The main distinctive features of some of the most recent concepts and their performance characteristics, with a focus on spatial resolution and sensitivity, are reviewed. The trade-offs between the various performance characteristics, desired capabilities, and cost that need to be considered when designing a dedicated brain scanner are presented. Finally, the aspirational goals for future-generation scanners, some of the factors that have contributed to the current status, and how recent advances may affect future developments in dedicated brain PET instrumentation are briefly discussed.

引用

页码：1044 / 1052

页数：9

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