Pancreas transplantation

被引:263
作者
White, Steve A. [1 ]
Shaw, James A. [2 ]
Sutherland, David E. R. [3 ]
机构
[1] Freeman Rd Hosp, Dept Hepatopancreatobiliary & Transplantat Surg, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England
[2] Univ Newcastle, Ctr Diabet, Newcastle Upon Tyne, Tyne & Wear, England
[3] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA
基金
英国医学研究理事会;
关键词
QUALITY-OF-LIFE; FREE MAINTENANCE IMMUNOTHERAPY; SIMULTANEOUS CADAVER PANCREAS; DONOR KIDNEY-TRANSPLANTATION; DEPENDENT DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; LIVING-RELATED DONOR; LONG-TERM; SINGLE-CENTER; RENAL-TRANSPLANTATION;
D O I
10.1016/S0140-6736(09)60609-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since the introduction of pancreas transplantation more than 40 years ago, efforts to develop more minimally invasive techniques for endocrine replacement therapy have been in progress, yet this surgical procedure still remains the treatment of choice for diabetic patients with end-stage renal failure. Many improvements have been made in the surgical techniques and immunosuppressive regimens, both of which have contributed to an increasing number of indications for pancreas transplantation. This operation can be justified on the basis that patients replace daily injections of insulin with an improved quality of life but at the expense of a major surgical procedure and lifelong immunosuppression. The various indications, categories, and outcomes of patients having a pancreas transplant are discussed, particularly with reference to the effect on long-term diabetic complications.
引用
收藏
页码:1808 / 1817
页数:10
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