Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity

被引：20

作者：

Souza-Moreira, Tatiana M. ^{[1
,2
]}

Severi, Juliana A. ^{[1
]}

Rodrigues, Edvanio Ramos ^{[1
]}

de Paula, Mayara Ivani ^{[1
]}

Freitas, Jolindo A. ^{[1
]}

Vilegas, Wagner ^{[2
]}

Pietro, Rosemeire C. L. R. ^{[1
]}

机构：

[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Araraquara, Brazil

[2] Sao Paulo State Univ UNESP, Dept Organ Chem, Araraquara, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 17期

基金：

巴西圣保罗研究基金会;

关键词：

Antifungal agent; myricetin; quercetin; Plinia cauliflora; non-albicans; dermatophyte; EPIDEMIOLOGY; JABOTICABA;

D O I：

10.1080/14786419.2018.1460827

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 mu g/mL), C. parapsilosis (78 mu g/mL), C. krusei (19 mu g/mL), Trichophyton rubrum (78 mu g/mL) and Microsporum canis (156 mu g/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum.

引用

页码：2579 / 2582

页数：4