Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

被引：145

作者：

Xiang, Hui-Jing ^{[1
,2
]}

Deng, Qiao ^{[1
,2
]}

An, Lu ^{[3
,4
]}

Guo, Min ^{[1
,2
]}

Yang, Shi-Ping ^{[3
,4
]}

Liu, Jin-Gang ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

[3] Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China

[4] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 01期

关键词：

NANOPLATFORM; NITROSYL;

D O I：

10.1039/c5cc07006f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform(Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.

引用

页码：148 / 151

页数：4

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