Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy

被引:3
作者
Zhang, Yu [1 ,2 ]
Xiao, Jiang [1 ]
Zhang, Wen [1 ]
Han, Ning [1 ]
Yang, Di [1 ]
Liu, Wei [1 ]
Zeng, Hui [3 ,4 ]
Han, Junyan [3 ,4 ]
Zhao, Hongxin [1 ,2 ]
机构
[1] Capital Med Univ, Beijing Ditan Hosp, Clin & Res Ctr Infect Dis, 8 Jingshun Dongjie, Beijing 100015, Peoples R China
[2] Peking Univ, Dept Infect Dis, Ditan Teaching Hosp, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing, Peoples R China
[4] Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China
关键词
Non-nucleoside reverse transcriptase inhibitors; protease inhibitors; highly active antiretroviral therapy; hypertriglyceridemia; INHIBITOR-BASED HAART; CARDIOVASCULAR-DISEASE; DYSLIPIDEMIA; RISK; LIPOPROTEINS; ACTIVATION; RESISTANCE; PROFILES; DECLINE; IMPACT;
D O I
10.3855/jidc.12519
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Introduction: The objective of this study was to investigate changes in serum lipids among HIV-infected patients switching from nonnucleoside-reverse transcriptase inhibitors (NNRTI) to protease inhibitor (PI)-based highly active antiretroviral therapy (HAART), and to determine if changes of lipid profiles impacted the monocyte subsets recovery. Methodology: Fifty-seven subjects who switched from NNRTIs to PI-based HAART (NNRTIs to PI group) and fifty-five subjects who initially started with PI-based HAART (initial PI group) were recruited. According to their baseline triglyceride (TG) levels, the NNRTIs to PI and initial PI groups were further divided into non-hypertriglyceridemia and hypertriglyceridemia subgroups, respectively. The effects of PI-based HAART on lipid profiles and monocyte subsets were analyzed. Results: At 48 weeks, the TG changes in the NNRTIs to PI group was higher than that of the initial PI group. The increases of serum TG levels in the initial PI non-hypertriglyceridemia group was greater than that of the NNRTIs to PI non-hypertriglyceridemia group. For the hypertriglyceridemia group at baseline, significant increment in TG levels were observed in the NNRTIs to PI hypertriglyceridemia group. The percentages of circulating CD14(high)CD16(+) and CD14(low)CD16(+) subsets were elevated in the two groups. At 48 weeks, the proportion of CD14(high)CD16(+) monocytes declined gradually, and the proportion of CD14(low)CD16(+) monocytes decreased independently of the TG level. Conclusions: For non-hypertriglyceridemia individuals at baseline, PI-based regimens increased the TG level in the initial PI group. For the NNRTIs to PI hypertriglyceridemia group, PI-based regimens reinforced HAART-related hypertriglyceridemia.
引用
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页码:528 / +
页数:11
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