Impact of HIV infection on aging and immune status

被引：14

作者：

Blanco, Jose-Ramon ^{[1
]}

Negredo, Eugenia ^{[2
,3
]}

Bernal, Enrique ^{[4
]}

Blanco, Julia ^{[5
,6
]}

机构：

[1] Hosp Univ San Pedro, Serv Enfermedades Infecciosas, Ctr Invest Biomed Rioja CIBIR, La Rioja, Spain

[2] Germans Trias & Pujol Univ Hosp, Lluita Sida Fdn, Badalona, Spain

[3] Cent Univ Catalonia Uvic UCC, Univ Vic, Fac Med, Ctr Hlth & Social Care Res CESS, Catalonia, Spain

[4] Univ Murcia, Hosp Gen Univ Reina Sofia, Unidad Enfermedades Infecciosas, Murcia, Spain

[5] AIDS Res Inst IrsiCaixa, Barcelona, Spain

[6] Univ Vic Cent Catalunya UVIC UCC, Vic, Spain

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2021年 / 19卷 / 06期

关键词：

Aging; antiretroviral therapy; comorbidity; HIV; immune activation; inflammation; HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC KIDNEY-DISEASE; T-CELL-ACTIVATION; MICROBIAL TRANSLOCATION; ANTIRETROVIRAL THERAPY; SOLUBLE CD14; RALTEGRAVIR INTENSIFICATION; UNINFECTED INDIVIDUALS; CARDIOVASCULAR-DISEASE; CIGARETTE-SMOKING;

D O I：

10.1080/14787210.2021.1848546

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Thanks to antiretroviral therapy (ART), persons living with HIV (PLWH), have a longer life expectancy. However, immune activation and inflammation remain elevated, even after viral suppression, and contribute to morbidity and mortality in these individuals. Areas covered: We review aspects related to immune activation and inflammation in PLWH, their consequences, and the potential strategies to reduce immune activation in HIV-infected individuals on ART. Expert opinion: When addressing a problem, it is necessary to thoroughly understand the topic. This is the main limitation faced when dealing with immune activation and inflammation in PLWH since there is no consensus on the ideal markers to evaluate immune activation or inflammation. To date, the different interventions that have addressed this problem by targeting specific mediators have not been able to significantly reduce immune activation or its consequences. Given that there is currently no curative intervention for HIV infection, more studies are necessary to understand the mechanism underlying immune activation and help to identify potential therapeutic targets that contribute to improving the life expectancy of HIV-infected individuals.

引用

页码：719 / 731

页数：13

共 172 条

[1] Kidney Dysfunction and Markers of Inflammation in the Multicenter AIDS Cohort Study [J].

Abraham, Alison G. ;

Darilay, Annie ;

McKay, Heather ;

Margolick, Joseph B. ;

Estrella, Michelle M. ;

Palella, Frank J., Jr. ;

Bolan, Robert ;

Rinaldo, Charles R. ;

Jacobson, Lisa P. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (07) :1100-1110

[2] Kidney disease in antiretroviral-naive HIV-positive adults with high CD4 counts: prevalence and predictors of kidney disease at enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial [J].

Achhra, A. C. ;

Mocroft, A. ;

Ross, M. J. ;

Ryom, L. ;

Lucas, G. M. ;

Furrer, H. ;

Neuhaus, J. ;

Somboonwit, C. ;

Kelly, M. ;

Gatell, J. M. ;

Wyatt, C. M. .

HIV MEDICINE, 2015, 16 :55-63

[3]

Adih William K, 2011, J Int Assoc Physicians AIDS Care (Chic), V10, P5, DOI 10.1177/1545109710384505

[4] Kidney Disease in HIV Infection [J].

Alfano, Gaetano ;

Cappelli, Gianni ;

Fontana, Francesco ;

Di Lullo, Luca ;

Di Iorio, Biagio ;

Bellasi, Antonio ;

Guaraldi, Giovanni .

JOURNAL OF CLINICAL MEDICINE, 2019, 8 (08)

[5] Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients [J].

Ancuta, Petronela ;

Kamat, Anupa ;

Kunstman, Kevin J. ;

Kim, Eun-Young ;

Autissier, Patrick ;

Wurcel, Alysse ;

Zaman, Tauheed ;

Stone, David ;

Mefford, Megan ;

Morgello, Susan ;

Singer, Elyse J. ;

Wolinsky, Steven M. ;

Gabuzda, Dana .

PLOS ONE, 2008, 3 (06)

[6]

Appay V, 2016, CURRENT OPINION HIV, V11

[7] Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients [J].

Appay, Victor ;

Fastenackels, Solene ;

Katlama, Christine ;

Ait-Mohand, Hocine ;

Schneider, Luminita ;

Guihot, Amelie ;

Keller, Michael ;

Grubeck-Loebenstein, Beatrix ;

Simon, Anne ;

Lambotte, Olivier ;

Hunt, Peter W. ;

Deeks, Steven G. ;

Costagliola, Dominique ;

Autran, Brigitte ;

Sauce, Delphine .

AIDS, 2011, 25 (15) :1813-1822

[8] Cohort profile: The Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) study [J].

Bagkeris, Emmanouil ;

Burgess, Laura ;

Mallon, Patrick W. ;

Post, Frank A. ;

Boffito, Marta ;

Sachikonye, Memory ;

Anderson, Jane ;

Asboe, David ;

Garvey, Lucy ;

Vera, Jaime ;

Williams, Ian ;

Johnson, Margaret ;

Babalis, Daphne ;

De Francesco, Davide ;

Winston, Alan ;

Sabin, Caroline A. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2018, 47 (05) :1391-+

[9]

Baker JV, 2020, CROI 2020 MACH 2020

[10] Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals [J].

Beck, James M. ;

Schloss, Patrick D. ;

Venkataraman, Arvind ;

Twigg, Homer, III ;

Jablonski, Kathleen A. ;

Bushman, Frederic D. ;

Campbell, Thomas B. ;

Charlson, Emily S. ;

Collman, Ronald G. ;

Crothers, Kristina ;

Curtis, Jeffrey L. ;

Drews, Kimberly L. ;

Flores, Sonia C. ;

Fontenot, Andrew P. ;

Foulkes, Mary A. ;

Frank, Ian ;

Ghedin, Elodie ;

Huang, Laurence ;

Lynch, Susan V. ;

Morris, Alison ;

Palmer, Brent E. ;

Schmidt, Thomas M. ;

Sodergren, Erica ;

Weinstock, George M. ;

Young, Vincent B. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 192 (11) :1335-1344

← 1 2 3 4 5 6 7 8 9 10 →