Biomaterials applications of cyclic polymers

被引:43
作者
Golba, Bianka [1 ]
Benetti, Edmondo M. [2 ,3 ]
De Geest, Bruno G. [1 ]
机构
[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium
[2] Swiss Fed Inst Technol, Dept Mat, Lab Surface Sci & Technol, Zurich, Switzerland
[3] Swiss Fed Labs Mat Sci & Technol Empa, Biointerfaces, St Gallen, Switzerland
关键词
Cyclic polymers; Polymer topology; Biodistribution; Pharmacokinetics; Drug delivery; Gene delivery; Biointerfaces;
D O I
10.1016/j.biomaterials.2020.120468
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Cyclic polymers are an intriguing class of polymers due to their lack of chain ends. This unique architecture combined with steric constraints adorn cyclic polymers as well as nano-, micro- and macro-scale materials containing cyclic polymers with distinctive physicochemical properties which can have a profound effect on the performance of these materials in a wide range of applications. Within a biomedical context, biomaterials based on cyclic polymers have shown very distinct properties in terms of biodistribution, pharmacokinetics, drug/gene delivery efficiency and surface activity. This review summarizes the applications of cyclic polymers in the field of biomaterials and highlights their potential in the biomedical field as well as addressing future challenges in this area.
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页数:13
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