Identification and characterization of murine IRAK-M

被引：39

作者：

Rosati, O ^{[1
]}

Martin, MU ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Pharmacol, D-30623 Hannover, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 05期

关键词：

IRAK-1; IRAK-M; mouse pelle-like-kinase; Toll/IL-1 rcceptor family; IL-1 signal transduction;

D O I：

10.1016/S0006-291X(02)00411-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu-IRAK-M), a mouse homologue to human IRAK-M (hu-IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：1472 / 1477

页数：6

共 25 条

[1] [Anonymous], SCI STKE
[2] Ausubel FM, 1995, SHORT PROTOCOLS MOL
[3] TARF6 is a signal transducer for interleukin-1
Cao, ZD
Xiong, J
Takeuchi, M
Kurama, T
Goeddel, DV
[J]. NATURE, 1996, 383 (6599) : 443 - 446
[4] IRAK: A kinase associated with the interleukin-1 receptor
Cao, ZD
Henzel, WJ
Gao, XO
[J]. SCIENCE, 1996, 271 (5252) : 1128 - 1131
[5] Chuang TH, 2002, J LEUKOCYTE BIOL, V71, P538
[6] MULTIPLE SEQUENCE ALIGNMENT WITH HIERARCHICAL-CLUSTERING
CORPET, F
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (22) : 10881 - 10890
[7] IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability
Jensen, LE
Whitehead, AS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) : 29037 - 29044
[8] Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
Kanakaraj, P
Schafer, PH
Cavender, DE
Wu, Y
Ngo, K
Grealish, PF
Wadsworth, SA
Peterson, PA
Siekierka, JJ
Harris, CA
Fung-Leung, WP
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (12) : 2073 - 2079
[9] Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
Kirschning, CJ
Wesche, H
Ayres, TM
Rothe, M
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) : 2091 - 2097
[10] Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
Knop, J
Martin, MU
[J]. FEBS LETTERS, 1999, 448 (01) : 81 - 85

← 1 2 3 →