Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores

被引：63

作者：

Barve, Aabha ^{[1
]}

Lowry, Mark ^{[1
]}

Escobedo, Jorge O. ^{[1
]}

Huynh, Katherine T. ^{[1
]}

Hakuna, Lovemore ^{[1
]}

Strongin, Robert M. ^{[1
]}

机构：

[1] Portland State Univ, Dept Chem, Portland, OR 97207 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 60期

基金：

美国国家卫生研究院;

关键词：

HIGHLY SELECTIVE DETECTION; PLASMA HOMOCYSTEINE; FLUORESCENT SENSOR; THIOL COMPOUNDS; CYCLIC AMINES; GLUTATHIONE; DISEASE; PROBES; CHEMOSENSORS; AGGREGATION;

D O I：

10.1039/c4cc03527e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the detection of homocysteine over cysteine based upon characteristic differences between 5- and 6-membered heterocyclic amines formed upon reaction with aldehyde-bearing compounds. Homocysteine-derived thiazinane-4-carboxylic acids are more basic than cysteine-derived thiazolidines-4-carboxylic acids. Fluorescence enhancement in response to homocysteine is achieved by tuning pH and excitation wavelength.

引用

页码：8219 / 8222

页数：4

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