Assessment of oxidative/nitrosative stress biomarkers and DNA damage in Haemonchus contortus, following exposure to zinc oxide nanoparticles
被引:25
作者:
Esmaeilnejad, Bijan
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Urmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, IranUrmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, Iran
Esmaeilnejad, Bijan
[1
]
Samiei, Awat
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机构:
Urmia Univ, Fac Vet Med, Vet Parasitol, Orumiyeh, IranUrmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, Iran
Samiei, Awat
[2
]
Mirzaei, Yousef
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机构:
Urmia Univ, Fac Vet Med, Vet Parasitol, Orumiyeh, Iran
Soran Univ, Dept Biol, Fac Sci, Soran, IraqUrmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, Iran
Mirzaei, Yousef
[2
,3
]
Farhang-Pajuh, Farhad
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机构:
Shahid Chamran Univ Ahvaz, Vet Parasitol, Fac Vet Med, Ahvaz, Iran
Urmia Univ, Cent Lab, Orumiyeh, IranUrmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, Iran
Farhang-Pajuh, Farhad
[4
,5
]
机构:
[1] Urmia Univ, Dept Pathobiol, Fac Vet Med, Orumiyeh, Iran
[2] Urmia Univ, Fac Vet Med, Vet Parasitol, Orumiyeh, Iran
[3] Soran Univ, Dept Biol, Fac Sci, Soran, Iraq
[4] Shahid Chamran Univ Ahvaz, Vet Parasitol, Fac Vet Med, Ahvaz, Iran
Drug resistance in helminth parasites has incurred several difficulties to livestock industry and ranked among the top public health concerns. Therefore, seeking for new agents to control parasites is an urgent strategy. In the recent years, metallic nanoparticles have been considerably evaluated for anthelmintic effects. The current research was conducted to assess possible anthelmintic impacts of zinc oxide nanoparticles (ZnO-NPs) on a prevalent gastrointestinal nematode, H. contortus. Moreover, several biomarkers of oxidative/nitrosative stress and DNA damage were measured. Various concentrations of the nanoparticle were prepared and incubated with the worms for 24 hours. The parasite mobility, mortality rate, antioxidant enzymes activities (SOD, Catalase and GSH-Px), lipid peroxidation, total antioxidant status as well as nitric oxide (NO) contents and DNA damage were determined. ZnO-NPs exerted significant wormicidal effects via induction of oxidative/nitrosative stress and DNA damage. Conclusively, ZnO-NPs can be utilized as a novel and potential agent to control and treatment of helminth parasitic infections.
机构:
Qatar Univ, Biomed Res Ctr, POB 2713, Doha, QatarQatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
Giordo, Roberta
Nasrallah, Gheyath K.
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Qatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
Qatar Univ, Coll Hlth Sci, Dept Biomed Sci, QU Hlth, POB 2713, Doha, QatarQatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
Nasrallah, Gheyath K.
Al-Jamal, Ola
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Qatar Univ, Biomed Res Ctr, POB 2713, Doha, QatarQatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
Al-Jamal, Ola
Paliogiannis, Panagiotis
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Univ Sassari, Dept Med Surg & Expt Surg, Viale San Pietro 43, I-07100 Sassari, ItalyQatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
Paliogiannis, Panagiotis
Pintus, Gianfranco
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机构:
Univ Sharjah, Coll Hlth Sci, Dept Med Lab Sci, POB 27272, Sharjah, U Arab Emirates
Univ Sassari, Dept Biomed Sci, Viale San Pietro 43, I-07100 Sassari, ItalyQatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar
机构:
Def Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, IndiaDef Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, India
Shrivastava, Rupal
Kushwaha, Pramod
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Def Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, IndiaDef Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, India
Kushwaha, Pramod
Bhutia, Yang Chen
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Def Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, IndiaDef Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, India
Bhutia, Yang Chen
Flora, S. J. S.
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Def Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, IndiaDef Res & Dev Estab, Div Regulatory Toxicol, Jhansi Rd, Gwalior 474002, India