Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice

被引：9

作者：

Kokras, Nikolaos ^{[1
,2
]}

Poulogiannopoulou, Eleni ^{[1
]}

Sotiropoulos, Marinos G. ^{[1
,7
]}

Paravatou, Rafaella ^{[1
]}

Goudani, Eleni ^{[1
]}

Dimitriadou, Maria ^{[1
]}

Papakonstantinou, Electra ^{[1
]}

Doxastakis, George ^{[3
]}

Perrea, Despina N. ^{[4
]}

Hloupis, George ^{[3
]}

Angelis, Apostolis ^{[5
]}

Argyropoulou, Aikaterini ^{[5
]}

Tsarbopoulos, Anthony ^{[1
,6
]}

Skaltsounis, Alexios-Leandros ^{[5
]}

Dalla, Christina ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pharmacol, Mikras Asias 75, Athens 11527, Greece

[2] Natl & Kapodistrian Univ Athens, Eginit Hosp, Med Sch, Dept Psychiat 1, Vas Sofias Ave 7274, Athens 11528, Greece

[3] Univ West Attica, Sch Engn, Dept Elect & Elect Engn, Elect Devices & Mat Lab, Agiou Spiridonos 28, Athens 12243, Greece

[4] Natl & Kapodistrian Univ Athens, Med Sch, Lab Expt Surg & Surg Res NS Christeas, Mikras Asias 75, Athens 11521, Greece

[5] Natl & Kapodistrian Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens 15771, Greece

[6] Goulandris Nat Hist Museum, Bioanalyt Dept, GAIA Res Ctr, Othonos 100, Athens 14562, Greece

[7] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Hale BTM 9002AA,60 Fenwood Rd, Boston, MA 02115 USA

来源：

MOLECULES | 2020年 / 25卷 / 21期

关键词：

olive oil; Sideritis; monoamines; aminoacids; cognition; behavior; CENTRAL-NERVOUS-SYSTEM; ANTIOXIDANT ACTIVITY; SEX-DIFFERENCES; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; RAT; HYDROXYTYROSOL; MEMORY; STRESS; TAURINE;

D O I：

10.3390/molecules25215000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to determine the cognitive and behavioral effects of extra virgin olive oil total phenolic content (TPC) and Sideritis (SID) extracts in female mice, and identify the associated neurochemical changes in the hippocampus and the prefrontal cortex. All animals received intraperitoneal low or high doses of TPC, SID or vehicle treatment for 7 days and were subjected to the Open Field (OF), Novel Object Recognition (NOR) and Tail Suspension Test (TST). The prefrontal cortex and hippocampus were dissected for analysis of neurotransmitters and aminoacids with high performance liquid chromatography with electrochemical detection (HPLC-ED). Both TPC doses enhanced vertical activity and center entries in the OF, which could indicate an anxiolytic-like effect. In addition, TPC enhanced non-spatial working memory and, in high doses, exerted antidepressant effects. On the other hand, high SID doses remarkably decreased the animals' overall activity. Locomotor and exploratory activities were closely associated with cortical increases in serotonin turnover induced by both treatments. Cognitive performance was linked to glutamate level changes. Furthermore, TPC reduced cortical taurine levels, while SID reduced cortical aspartate levels. TPC seems to have promising cognitive, anxiolytic and antidepressant effects, whereas SID has sedative effects in high doses. Both extracts act in the brain, but their specific actions and properties merit further exploration.

引用

页数：27