Autologous hematopoietic stem cell transplantation with inadequate stem cell dose in patients with non-Hodgkin lymphoma

被引：2

作者：

Liu, Weiping ^{[1
]}

Wu, Meng ^{[1
]}

Xie, Yan ^{[1
]}

Zhang, Chen ^{[1
]}

Ping, Lingyan ^{[1
]}

Feng, Feier ^{[1
]}

Leng, Xin ^{[1
]}

Mi, Lan ^{[1
]}

Wang, Xiaopei ^{[1
]}

Zhu, Jun ^{[1
]}

Song, Yuqin ^{[1
]}

机构：

[1] Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Lymphoma, 52 Fucheng Rd, Beijing 100142, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 02期

关键词：

Hematopoietic stem cell transplantation; survival; safety; lymphoma; Non-Hodgkin's; PROMOTES PLATELET ENGRAFTMENT; T-CELL; AMERICAN SOCIETY; GUIDELINES; THERAPY; CHEMOTHERAPY; MOBILIZATION; PROGNOSIS; SURVIVAL; OUTCOMES;

D O I：

10.1080/10428194.2020.1834092

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known regarding the outcome of lymphoma patients undergoing autologous hematopoietic stem cell transplantation (AHSCT) using inadequate hematopoietic stem cell (HSC) doses. Fifty-six patients were enrolled in the study, and the cohort was subdivided into two groups according to the infusion dose: < 1 x 10(6)/kg (poor HSC group) and 1-2 x 10(6)/kg (unfavorable HSC group). Compared with the unfavorable group, the poor HSC group had a longer median time to neutrophil (13 vs. 11 days,p = .007) and platelet engraftment (17 vs. 13 days,p = .024). CD34+ cell infusion dose of < 1 x 10(6)/kg was the only risk factor for neutrophil and platelet engraftment. The expected 3-year progression-free survival and overall survival rates for the whole cohort were 53% and 66%, and no statistical difference was observed between two groups. In conclusion, inadequate HSC infusion dose did not negatively impact AHSCT patient survival but significantly prolonged the time to hematopoietic engraftment.

引用

页码：323 / 329

页数：7

共 28 条

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