New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

被引：92
作者：
Honda, T
Finlay, HJ
Gribble, GW
Suh, N
Sporn, MB
机构：
[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03755
[2] DARTMOUTH COLL,DEPT CHEM,HANOVER,NH 03755
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期
关键词：
D O I：
10.1016/S0960-894X(97)00279-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New derivatives of 3-oxoolean-1-en-28 oic acid and 3-oxours-1-en-28-oic acid were synthesized. Nine of them showed significant inhibitory activity against interferon-gamma-induced nitric oxide production in mouse macrophages when assayed at the 1 mu M level. 3,12-Dioxoolean-1,9-dien-28-oic acid (3) had the highest activity (IC50, 0.9 mu M). (C) 1997 Elsevier Science Ltd.
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页码：1623 / 1628
页数：6
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