A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions

被引:20
|
作者
Nozaki, Hiroaki [1 ]
Shimohata, Takayoshi [1 ]
Kanbayashi, Takashi [3 ]
Sagawa, Youhei [3 ]
Katada, Shin-ichi [1 ]
Satoh, Masahisa [1 ]
Onodera, Osamu [2 ]
Tanaka, Keiko [1 ]
Nishizawa, Masatoyo [1 ]
机构
[1] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata 9518585, Japan
[2] Niigata Univ, Brain Res Inst, Ctr Bioresource Based Res, Dept Mol Neurosci, Niigata 9518585, Japan
[3] Akita Univ, Dept Neuropsychiat, Akita 010, Japan
关键词
Hypersomnia; Hypothalamus; Aquaporin; 4; Orexin (hypocretin); NEUROMYELITIS-OPTICA; MULTIPLE-SCLEROSIS; ANTI-AQUAPORIN-4; ANTIBODY; MARKER; BRAIN;
D O I
10.1016/j.sleep.2007.11.022
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent studies have demonstrated that hypothalamic lesions associated with brain tumor, head trauma, and encephalopathy can cause symptomatic hypersomnia with a reduced orexin (hypocretin) level in the cerebrospinal fluid (CSF). Aquaporin 4 (AQP4) a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated. We report the case of a patient with a serum anti-AQP4 antibody who presented with recurrent hypersomnia, symmetrical hypothalamic lesions with long spinal cord lesions oil MRI, and a reduced CSF orexin (hypocretin) level, all of which were improved simultaneously by steroid therapy. Further studies Should be performed to determine the roles of anti-AQP4 antibody positivity in patients with hypersomnia associated with orexin (hypocretin) deficiency and hypothalamic lesions. (c) 2009 Published by Elsevier B.V.
引用
收藏
页码:253 / 255
页数:3
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