Cellular mechanisms and physiological consequences of redox-dependent signalling

被引：1616
作者：
Holmstroem, Kira M. [1 ]
Finkel, Toren [1 ]
机构：
[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 06期
基金：
美国国家卫生研究院;
关键词：
PROTEIN-TYROSINE PHOSPHATASES; HYDROGEN-PEROXIDE; LIFE-SPAN; REVERSIBLE INACTIVATION; OXIDATIVE STRESS; PYRUVATE-KINASE; SELF-RENEWAL; DNA-DAMAGE; STEM-CELLS; ROS LEVELS;
D O I：
10.1038/nrm3801
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Reactive oxygen species (ROS), which were originally characterized in terms of their harmful effects on cells and invading microorganisms, are increasingly implicated in various cell fate decisions and signal transduction pathways. The mechanism involved in ROS-dependent signalling involves the reversible oxidation and reduction of specific amino acids, with crucial reactive Cys residues being the most frequent target. In this Review, we discuss the sources of ROS within cells and what is known regarding how intracellular oxidant levels are regulated. We further discuss the recent observations that reduction-oxidation (redox)-dependent regulation has a crucial role in an ever-widening range of biological activities-from immune function to stem cell self-renewal, and from tumorigenesis to ageing.
引用
收藏
页码：411 / 421
页数：11
相关论文
共 119 条
[1]   Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity [J].
Abbas, Hussein A. ;
Maccio, Daniela R. ;
Coskun, Suleyman ;
Jackson, James G. ;
Hazen, Amy L. ;
Sills, Tiffany M. ;
You, M. James ;
Hirschi, Karen K. ;
Lozano, Guillermina .
CELL STEM CELL, 2010, 7 (05) :606-617
[2]   Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals [J].
Aguirre, Jesus ;
Lambeth, J. David .
FREE RADICAL BIOLOGY AND MEDICINE, 2010, 49 (09) :1342-1353
[3]   Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses [J].
Anastasiou, Dimitrios ;
Poulogiannis, George ;
Asara, John M. ;
Boxer, Matthew B. ;
Jiang, Jian-kang ;
Shen, Min ;
Bellinger, Gary ;
Sasaki, Atsuo T. ;
Locasale, Jason W. ;
Auld, Douglas S. ;
Thomas, Craig J. ;
Vander Heiden, Matthew G. ;
Cantley, Lewis C. .
SCIENCE, 2011, 334 (6060) :1278-1283
[4]   Epidermal growth factor (EGF)-induced generation of hydrogen peroxide - Role in EGF receptor-mediated tyrosine phosphorylation [J].
Bae, YS ;
Kang, SW ;
Seo, MS ;
Baines, IC ;
Tekle, E ;
Chock, PB ;
Rhee, SG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (01) :217-221
[5]   Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2 [J].
Baker, Brooke M. ;
Nargund, Amrita M. ;
Sun, Tiffany ;
Haynes, Cole M. .
PLOS GENETICS, 2012, 8 (06)
[6]   Mitochondria, oxidants, and aging [J].
Balaban, RS ;
Nemoto, S ;
Finkel, T .
CELL, 2005, 120 (04) :483-495
[7]   SIRT3 regulation of mitochondrial oxidative stress [J].
Bause, Alexandra S. ;
Haigis, Marcia C. .
EXPERIMENTAL GERONTOLOGY, 2013, 48 (07) :634-639
[8]   Genetically encoded fluorescent indicator for intracellular hydrogen peroxide [J].
Belousov, VV ;
Fradkov, AF ;
Lukyanov, KA ;
Staroverov, DB ;
Shakhbazov, KS ;
Terskikh, AV ;
Lukyanov, S .
NATURE METHODS, 2006, 3 (04) :281-286
[9]   Modulation of intracellular ROS levels by TIGAR controls autophagy [J].
Bensaad, Karim ;
Cheung, Eric C. ;
Vousden, Karen H. .
EMBO JOURNAL, 2009, 28 (19) :3015-3026
[10]   The sites and topology of mitochondrial superoxide production [J].
Brand, Martin D. .
EXPERIMENTAL GERONTOLOGY, 2010, 45 (7-8) :466-472
12345678910