Subsequent Primary Neoplasms Risks, Risk Factors, Surveillance, and Future Research

被引：17

作者：

Hawkins, Michael ^{[1
,2
]}

Bhatia, Smita ^{[3
]}

Henderson, Tara O. ^{[4
]}

Nathan, Paul C. ^{[5
]}

Yan, Adam ^{[5
]}

Teepen, Jop C. ^{[6
]}

Morton, Lindsay M. ^{[7
]}

机构：

[1] Univ Birmingham, Epidemiol, Ctr Childhood Canc Survivor Studies, Inst Appl Hlth Res, Robert Aitken Bldg, Birmingham B15 2TY, W Midlands, England

[2] Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Robert Aitken Bldg, Birmingham B15 2TY, W Midlands, England

[3] Univ Alabama Birmingham, Inst Canc Outcomes & Survivorship, Birmingham, AL USA

[4] Univ Chicago, Comer Childrens Hosp, Chicago, IL 60637 USA

[5] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada

[6] Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands

[7] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2020年 / 67卷 / 06期

关键词：

Subsequent primary neoplasms; Second malignant neoplasms; Second primary cancers; Secondary cancers; Radiotherapy; Chemotherapy; Genetic variation; Genetic susceptibility; Surveillance; Screening; Follow-up guidelines; BREAST-CANCER RISK; YOUNG-ADULT CANCER; 2ND MALIGNANT NEOPLASMS; TP53 MUTATION CARRIERS; LONG-TERM SURVIVORS; CHILDHOOD-CANCER; FOLLOW-UP; RADIATION-THERAPY; 5-YEAR SURVIVORS; CHEST RADIATION;

D O I：

10.1016/j.pcl.2020.07.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The authors’ objective is to provide a brief update on recent advances in knowledge relating to subsequent primary neoplasms developing in survivors of childhood cancer. This includes a summary of established large-scale cohorts, risks reported, and contrasts with results from recently established large-scale cohorts of survivors of adolescent and young adult cancer. Recent evidence is summarized concerning the role of radiotherapy and chemotherapy for childhood cancer and survivor genomics in determining the risk of subsequent primary neoplasms. Progress with surveillance, screening, and clinical follow-up guidelines is addressed. Finally, priorities for future research are outlined. © 2020 Elsevier Inc.

引用

页码：1135 / 1154

页数：20

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