Prognostic models for pre-eclampsia

Between 3% and 5% of pregnant women are affected by pre-eclampsia at some point in the pregnancy. For the past 50 years screening for prodromes and symptoms of pre-eclampsia consisted of blood pressure measurements at regular intervals together with urinalysis for proteinuria and alertness for the development of edema during the second and third trimester. The recent development of prognostic models has made it possible to recognize an increased risk for the subsequent development of pre-eclampsia in the asymptomatic patient in the first trimester of pregnancy. Studies have shown that prophylactic intake of acetylsalicylic acid beginning in the first trimester can reduce the incidence of later pre-eclampsia by 60%. Prognostic models based on serum biomarkers and Doppler ultrasound imaging provide a conclusive concept for prevention and treatment of pre-eclampsia.