Activated IL-22 pathway occurs in the muscle tissues of patients with polymyositis or dermatomyositis and is correlated with disease activity

被引：18

作者：

Ciccia, Francesco ^{[1
]}

Rizzo, Aroldo ^{[2
]}

Alessandro, Riccardo ^{[3
]}

Guggino, Giuliana ^{[1
]}

Maugeri, Rosario ^{[4
]}

Saieva, Laura ^{[3
]}

Cannizzaro, Alessandra ^{[2
]}

Giardina, AnnaRita ^{[1
]}

De Leo, Giacomo ^{[3
]}

Iacopino, Domenico Gerardo ^{[4
]}

Triolo, Giovanni ^{[1
]}

机构：

[1] Univ Palermo, Sez Reumatol, Dipartimento Biomed Med Interna & Specialist, I-90127 Palermo, Italy

[2] Univ Palermo, Sez Anat Patol, Azienda Osped Osped Riuniti Villa Sofia Cervello, I-90127 Palermo, Italy

[3] Univ Palermo, Dipartimento Biopatol & Biotecnol Med & Forensi, I-90127 Palermo, Italy

[4] Univ Palermo, Dipartimento Biomed Sperimentale & Neurosci Clin, I-90127 Palermo, Italy

来源：

RHEUMATOLOGY | 2014年 / 53卷 / 07期

关键词：

IL-22; IL-22R1; IL-17; p-STAT3; polymyositis; dermatomyositis; EXPRESSION; CYTOKINES; MYOSITIS; CELLS;

D O I：

10.1093/rheumatology/keu005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methods. Levels of IL-22, IL-22R1, IL-22BP and STAT3 mRNA were quantified by RT-PCR. The expression of IL-22, IL-22R1, IL-22BP and p-STAT3 was also analysed using immunohistochemistry. Results. Significant modulation of the IL-22 pathway was observed in inflammatory myopathic tissues. In particular, a significant overexpression of IL-22 at the protein but not the mRNA level was observed in PM/DM tissues and was correlated with myositis activity. IL-22R1 aberrant expression was also observed among infiltrating mononuclear cells and necrotic muscle cells. IL-22BP, which inhibits IL-22 signalling, was expressed only in some muscle fibres in PM/DM patients. Conclusion. Our findings indicate that the IL-22 pathway is activated in inflammatory myopathic tissues and may be involved in the induction of muscle inflammatory processes and muscle necrosis.

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收藏

页码：1307 / 1312

页数：6

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