Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes

被引：14

作者：

Nacher, M

Silachamroon, U

Singhasivanon, P

Wilairatana, P

Phumratanaprapin, W

Fontanet, A

Looareesuwan, S

机构：

[1] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand

[2] Inst Pasteur, Unite Rech & Expertise Epidemiol Malad Emergentes, Paris, France

[3] Shoklo Malaria Res Unit, Mae Sot, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 07期

关键词：

D O I：

10.1128/AAC.48.7.2751-2752.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated patients (n = 792) than in chloroquine-treated patients (n = 695) (RR = 0.29; 95% CI = 0.2 to 0.40; P < 0.0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria.

引用

页码：2751 / 2752

页数：2

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