Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

被引：24
|
作者：
Ellis, Gregory A. [1 ]
Wyche, Thomas P. [1 ]
Fry, Charles G. [2 ]
Braun, Doug R. [1 ]
Bugni, Tim S. [1 ]
机构：
[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
MARINE DRUGS | 2014年 / 12卷 / 02期
关键词：
Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus; A-C; STREPTOMYCES;
D O I：
10.3390/md12021013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-C-13 glucose, and analysis of a C-13-C-13 COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
引用
收藏
页码：1013 / 1022
页数：10
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