Factor V Leiden:: The Copenhagen City Heart Study and 2 meta-analyses

被引:156
作者
Juul, K
Tybjærg-Hansen, A
Steffensen, R
Kofoed, S
Jensen, G
Nordestgaard, BG [1 ]
机构
[1] Herlev Univ Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark
[2] Univ Copenhagen Hosp, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark
[3] Cent Hosp Hillerod, Dept Med B, DK-3400 Hillerod, Denmark
[4] Gentofte Univ Hosp, Dept Vasc Surg, Gentofte, Denmark
[5] Univ Copenhagen, Bispebjerg Hosp, Copenhagen City Heart Study, Copenhagen, Denmark
关键词
D O I
10.1182/blood-2002-01-0111
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischernic stroke (IS), or non-MI ischernic heart disease (non-MI-IHD). The design was 3 case-control studies and 3 prospective studies with 21 years' follow-up. The setting was the general population in Copenhagen, Denmark. The participants for The Copenhagen City Heart Study were 20- to 95-year-old participants without cardiovascular disease (control population, n=7907) or participants diagnosed with MI (n=469), IS (n=231), or non-MI-IHD (n=365). In addition, 3 independent patient populations from Copenhagen University Hospital with MI (n=493), IS (n=231), or non-MI-IHD (n=448) were included. We measured FVL genotype; major cardiovascular risk factors; and MI, IS, and non-MI-IHD incidence and prevalence. Prevalences of FVL heterozygotes and homozygotes in control subjects from the general population were 7.7% and 0.2%. Odds ratios and relative risks of MI in FVL carriers (heterozygotes + homozygotes) versus non-carriers were 1.24 (95% confidence interval [CI], 0.91-1.69) and 0.83 (0.58-1.20) in case-control and prospective studies, respectively. Corresponding risks for IS were 0.92 (95% CI, 0.56-1.53) and 0.68 (0.45-1.04), and for non-MI-IHD 1.01 (95% CI, 0.71-1.44) and 0.97 (0.66-1.42). Findings from The Copenhagen City Heart Study suggest that FVL is not associated with MI, IS, or non-MI-IHD.
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收藏
页码:3 / 10
页数:8
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