Role of Helicobacter Pylori in Gastric Cancer: Advances and Controversies

被引：4
作者：
Meng, Wenbo [1 ,2 ,3 ]
Bai, Bing [1 ,2 ,3 ]
Sheng, Liang [2 ,3 ]
Li, Yan [4 ]
Yue, Ping [2 ,3 ]
Li, Xun [2 ,3 ]
Qiao, Liang [5 ]
机构：
[1] Lanzhou Univ, Dept Special Minimally Invas Surg, Hosp 1, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Biol Therapy & Regenerat Med Transformat Ctr Gans, Dept Gen Surg 2, Hepatopancreatobiliary Surg Inst Gansu Prov,Hosp, Lanzhou 730000, Gansu, Peoples R China
[3] Lanzhou Univ, Ctr Canc, Clin Med Coll, Lanzhou 730000, Gansu, Peoples R China
[4] Cleveland Clin, Dept Immunol, Cleveland, OH 44195 USA
[5] Univ Sydney, Westmead Hosp, Westmead Millennium Inst Med Res, Storr Liver Ctr,Dept Med, Sydney, NSW 2145, Australia
来源：
DISCOVERY MEDICINE | 2015年 / 20卷 / 111期
基金：
中国国家自然科学基金;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ABERRANT DNA METHYLATION; MUCOSAL INFLAMMATORY RESPONSES; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; ENDOSCOPIC RESECTION; STEM-CELLS; E-CADHERIN; VACUOLATING CYTOTOXIN; COCCOID FORMS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gastric cancer is one of the most common cancers of digestive system globally and Helicobacter pylori (HP) infection is believed to be a major risk factor. HP can be classified into different types based on the presence and expression level of CagA and VacA, and, when exposed to adverse environment, HP changes its phenotype from helical type to coccoid type, with each having different pathogenicity. The mechanisms of HP-induced gastric carcinogenesis and progression are complicated, including DNA nitration and oxidation induced by mutagenic factors, HP-induced epigenetic modifications, HP-induced disruption of the balance between cell proliferation and apoptosis, and HP-induced cancer cell invasion and metastasis. HP may also affect the biological function of cancer stem cells and induction of cell autophagy. The lipopolysaccharide produced by HP can act through toll-like receptor-4 (TLR-4) to induce gastric mucosal inflammation and is thereby linked to the development of gastric cancer.
引用
收藏
页码：285 / 293
页数：9
相关论文
共 102 条
  • [21] Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges
    Ding, Song-Ze
    Zheng, Peng-Yuan
    [J]. GUT PATHOGENS, 2012, 4
  • [22] Review article: the role of inflammation in the pathogenesis of gastric cancer
    Ernst, P
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1999, 13 : 13 - 18
  • [23] Immunoglobulin G antibody response to infection with coccoid forms of Helicobacter pylori
    Figueroa, G
    Faúndez, G
    Troncoso, M
    Navarrete, P
    Toledo, MS
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (05) : 1067 - 1071
  • [24] Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer:: an open-label, randomised controlled trial
    Fukase, Kazutoshi
    Kato, Mototsugu
    Kikuchi, Shogo
    Inoue, Kazuhiko
    Uemura, Naomi
    Okamoto, Shiro
    Terao, Shuichi
    Amagai, Kenji
    Hayashi, Shunji
    Asaka, Masahiro
    [J]. LANCET, 2008, 372 (9636) : 392 - 397
  • [25] Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice
    Gong, Ju-Hyun
    Cho, In-Hee
    Shin, Daekeun
    Han, Seon-Young
    Park, Sin-Hye
    Kang, Young-Hee
    [J]. LABORATORY INVESTIGATION, 2014, 94 (03) : 297 - 308
  • [26] Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
    Grady, WM
    Willis, J
    Guilford, PJ
    Dunbier, AK
    Toro, TT
    Lynch, H
    Wiesner, G
    Ferguson, K
    Eng, C
    Park, JG
    Kim, SJ
    Markowitz, S
    [J]. NATURE GENETICS, 2000, 26 (01) : 16 - 17
  • [27] Patterns of somatic mutation in human cancer genomes
    Greenman, Christopher
    Stephens, Philip
    Smith, Raffaella
    Dalgliesh, Gillian L.
    Hunter, Christopher
    Bignell, Graham
    Davies, Helen
    Teague, Jon
    Butler, Adam
    Edkins, Sarah
    O'Meara, Sarah
    Vastrik, Imre
    Schmidt, Esther E.
    Avis, Tim
    Barthorpe, Syd
    Bhamra, Gurpreet
    Buck, Gemma
    Choudhury, Bhudipa
    Clements, Jody
    Cole, Jennifer
    Dicks, Ed
    Forbes, Simon
    Gray, Kris
    Halliday, Kelly
    Harrison, Rachel
    Hills, Katy
    Hinton, Jon
    Jenkinson, Andy
    Jones, David
    Menzies, Andy
    Mironenko, Tatiana
    Perry, Janet
    Raine, Keiran
    Richardson, Dave
    Shepherd, Rebecca
    Small, Alexandra
    Tofts, Calli
    Varian, Jennifer
    Webb, Tony
    West, Sofie
    Widaa, Sara
    Yates, Andy
    Cahill, Daniel P.
    Louis, David N.
    Goldstraw, Peter
    Nicholson, Andrew G.
    Brasseur, Francis
    Looijenga, Leendert
    Weber, Barbara L.
    Chiew, Yoke-Eng
    [J]. NATURE, 2007, 446 (7132) : 153 - 158
  • [28] Fibroblast growth factor signaling in tumorigenesis
    Grose, R
    Dickson, C
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (02) : 179 - 186
  • [29] The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells
    Halder, Priyanka
    Datta, Chandreyee
    Kumar, Ranjeet
    Sharma, Arun Kumar
    Basu, Joyoti
    Kundu, Manikuntala
    [J]. CELLULAR MICROBIOLOGY, 2015, 17 (05) : 714 - 729
  • [30] The hallmarks of cancer
    Hanahan, D
    Weinberg, RA
    [J]. CELL, 2000, 100 (01) : 57 - 70
12345678910