The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance

被引:15
|
作者
Szakács, G [1 ]
Chen, GK [1 ]
Gottesman, MM [1 ]
机构
[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
关键词
multidrug resistance; P-glycoprotein; MDR1; ZNRD1; transcriptional regulation;
D O I
10.4161/cbt.3.4.743
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:382 / 384
页数:3
相关论文
共 50 条
  • [21] Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents
    Woodland, C
    Koren, G
    Wainer, IW
    Batist, G
    Ito, S
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2003, 81 (08) : 800 - 805
  • [22] Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Carnosic Acid
    Yu, Xiao-Ning
    Chen, Xue-Liang
    Li, Hao
    Li, Xiang-Xin
    Li, Hui-Qing
    Jin, Wen-Rui
    CHINESE JOURNAL OF PHYSIOLOGY, 2008, 51 (06): : 348 - 356
  • [23] Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo
    Qi, J
    Wang, SB
    Liu, GY
    Peng, H
    Wang, JH
    Zhu, ZP
    Yang, CZ
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 319 (04) : 1124 - 1131
  • [24] A bioassay for the activity of PSC 833 in human serum for modulation of P-glycoprotein-mediated multidrug resistance
    Uchiyama-Kokubu, N
    Watanabe, T
    Nakajima, M
    ANTI-CANCER DRUGS, 2000, 11 (07) : 583 - 590
  • [25] Lamellarins as Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance in a Human Colon Cancer Cell Line
    Plisson, Fabien
    Huang, Xiao-Cong
    Zhang, Hua
    Khalil, Zeinab
    Capon, Robert J.
    CHEMISTRY-AN ASIAN JOURNAL, 2012, 7 (07) : 1616 - 1623
  • [26] REVERSAL OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG-RESISTANCE BY PURE ANTIESTROGENS AND NOVEL TAMOXIFEN DERIVATIVES
    KIRK, J
    SYED, SK
    HARRIS, AL
    JARMAN, M
    ROUFOGALIS, BD
    STRATFORD, IJ
    CARMICHAEL, J
    BIOCHEMICAL PHARMACOLOGY, 1994, 48 (02) : 277 - 285
  • [27] Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells
    Iva Guberović
    Marko Marjanović
    Marija Mioč
    Katja Ester
    Irena Martin-Kleiner
    Tatjana Šumanovac Ramljak
    Kata Mlinarić-Majerski
    Marijeta Kralj
    Scientific Reports, 8
  • [28] Reversal effects of local anesthetics on P-glycoprotein-mediated cancer multidrug resistance
    Hu, Yong
    Qin, Xiaobing
    Cao, Haixia
    Yu, Shaorong
    Feng, Jifeng
    ANTI-CANCER DRUGS, 2017, 28 (03) : 243 - 249
  • [29] Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative
    Dale, IL
    Tuffley, W
    Callaghan, R
    Holmes, JA
    Martin, K
    Luscombe, M
    Mistry, P
    Ryder, H
    Stewart, AJ
    Charlton, P
    Twentyman, PR
    Bevan, P
    BRITISH JOURNAL OF CANCER, 1998, 78 (07) : 885 - 892
  • [30] Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer
    Cardoso, David S. P.
    Szemeredi, Nikoletta
    Spengler, Gabriella
    Mulhovo, Silva
    dos Santos, Daniel J. V. A.
    Ferreira, Maria-Jose U.
    PHARMACEUTICALS, 2021, 14 (09)