Genome-wide patterns of selection in 230 ancient Eurasians

被引：856

作者：

Mathieson, Iain ^{[1
]}

Lazaridis, Iosif ^{[1
,2
]}

Rohland, Nadin ^{[1
,2
]}

Mallick, Swapan ^{[1
,2
,3
]}

Patterson, Nick ^{[2
]}

Roodenberg, Songul Alpaslan

Harney, Eadaoin ^{[1
,3
]}

Stewardson, Kristin ^{[1
,3
]}

Fernandes, Daniel ^{[4
,5
]}

Novak, Mario ^{[4
,5
,6
]}

Sirak, Kendra ^{[4
,5
,7
]}

Gamba, Cristina ^{[4
,5
,8
]}

Jones, Eppie R. ^{[8
]}

Llamas, Bastien ^{[9
,10
]}

Dryomov, Stanislav ^{[11
,12
]}

Pickrell, Joseph ^{[1
]}

Luis Arsuaga, Juan ^{[13
,14
]}

Bermudez de Castro, Jose Maria ^{[15
]}

Carbonell, Eudald ^{[16
,17
]}

Gerritsen, Fokke ^{[18
]}

Khokhlov, Aleksandr ^{[19
]}

Kuznetsov, Pavel ^{[19
]}

Lozano, Marina ^{[16
,17
]}

Meller, Harald ^{[20
,21
]}

Mochalov, Oleg ^{[19
]}

Moiseyev, Vyacheslav ^{[22
]}

Rojo Guerra, Manuel A. ^{[23
]}

Roodenberg, Jacob ^{[24
]}

Maria Verges, Josep ^{[16
,17
]}

Krause, Johannes ^{[25
,26
]}

Cooper, Alan ^{[9
]}

Alt, Kurt W. ^{[20
,21
,27
,28
]}

Brown, Dorcas ^{[29
]}

Anthony, David ^{[29
]}

Lalueza-Fox, Carles ^{[30
]}

Haak, Wolfgang ^{[9
,10
,25
]}

Pinhasi, Ron ^{[4
,5
]}

Reich, David ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[4] Univ Coll Dublin, Sch Archaeol, Dublin 4, Ireland

[5] Univ Coll Dublin, Earth Inst, Dublin 4, Ireland

[6] Inst Anthropol Res, Zagreb 10000, Croatia

[7] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA

[8] Univ Dublin Trinity Coll, Smurfit Inst Genet, Dublin 2, Ireland

[9] Univ Adelaide, Sch Biol Sci, Australian Ctr Ancient DNA, Adelaide, SA 5005, Australia

[10] Univ Adelaide, Sch Environm Inst, Australian Ctr Ancient DNA, Adelaide, SA 5005, Australia

[11] Russian Acad Sci, Inst Mol & Cellular Biol, Siberian Branch, Lab Human Mol Genet, Novosibirsk 630090, Russia

[12] Russian Acad Sci, Inst Archaeol & Ethnog, Siberian Branch, Dept Paleolith Archaeol, Novosibirsk 630090, Russia

[13] Ctr Mixto UCM ISCIII Evoluc & Comportamiento Huma, Madrid 28040, Spain

[14] Univ Complutense Madrid, Fac Ciencias Geol, Dept Paleontol, E-28040 Madrid, Spain

[15] Ctr Nacl Invest Evoluc Humana CENIEH, Burgos 09002, Spain

[16] IPHES Inst Catala Paleoecol Humana & Evolucio Soc, Tarragona 43007, Spain

[17] Univ Rovira & Virgili, Area Prehist, Tarragona 43002, Spain

[18] Netherlands Inst Turkey, TR-34433 Istanbul, Turkey

[19] Volga State Acad Social Sci & Humanities, Samara 443099, Russia

[20] State Off Heritage Management & Archaeol, D-06114 Halle, Germany

[21] Archaeol Saxony Anhalt & State Museum Prehist, D-06114 Halle, Germany

[22] RAS, Peter Great Museum Anthropol & Ethnog Kunstkamera, St Petersburg 199034, Russia

[23] Univ Valladolid, Dept Prehist & Archaeol, E-47002 Valladolid, Spain

[24] Netherlands Inst Near East, NL-2300 RA Leiden, Netherlands

[25] Max Planck Inst Sci Human Hist, D-07745 Jena, Germany

[26] Univ Tubingen, Inst Archaeol Sci, D-72070 Tubingen, Germany

[27] Danube Private Univ, A-3500 Krems, Austria

[28] Univ Basel, Inst Prehist & Archaeol Sci, CH-4003 Basel, Switzerland

[29] Hartwick Coll, Dept Anthropol, Oneonta, NY 13820 USA

[30] CSIC Univ Pompeu Fabra, Inst Evolutionary Biol, Barcelona 08003, Spain

来源：

NATURE | 2015年 / 528卷 / 7583期

基金：

欧洲研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

GENETIC-DETERMINANTS; POSITIVE SELECTION; ASSOCIATION; LOCI; EDAR; IDENTIFICATION; POLYMORPHISMS; PIGMENTATION; ARCHITECTURE; POPULATIONS;

D O I：

10.1038/nature16152

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 BC, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 BC, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.

引用

页码：499 / +

页数：16

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