Colloidal RBC-Shaped, Hydrophilic, and Hollow Mesoporous Carbon Nanocapsules for Highly Efficient Biomedical Engineering

被引:198
作者
Chen, Yu [1 ]
Xu, Pengfei [2 ]
Wu, Meiying [1 ]
Meng, Qingshuo [2 ]
Chen, Hangrong [1 ]
Shu, Zhu [1 ]
Wang, Jin [1 ]
Zhang, Lingxia [1 ]
Li, Yaping [2 ]
Shi, Jianlin [1 ]
机构
[1] Chinese Acad Sci, State Lab High Performance Ceram & Superfine Micr, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
基金
上海市自然科学基金;
关键词
BREAST-CANCER METASTASIS; SILICA NANOPARTICLES; DRUG-DELIVERY; CELLS; RELEASE; NANOSTRUCTURES; NANOMEDICINE; NANOSPHERES; DOXORUBICIN; INHIBITION;
D O I
10.1002/adma.201400303
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A facile and versatile synthetic route (templated framework pyrolysis) toward the construction of a new colloidal carbon nanosystem based on red blood cell (RBC)-shaped, hydrophilic, and hollow mesoporous carbon nanocapsules (HMCNs) is developed for highly efficient biomedical engineering, including stimuli-responsive drug release, inhibiting the metastasis, and circumventing the multidrug resistance of cancer cells.
引用
收藏
页码:4294 / 4301
页数:8
相关论文
共 52 条
  • [1] Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine
    Ambrogio, Michael W.
    Thomas, Courtney R.
    Zhao, Yan-Li
    Zink, Jeffrey I.
    Stoddartt, J. Fraser
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) : 903 - 913
  • [2] Ananta JS, 2010, NAT NANOTECHNOL, V5, P815, DOI [10.1038/nnano.2010.203, 10.1038/NNANO.2010.203]
  • [3] pH-responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes
    Angelos, Sarah
    Yang, Ying-Wei
    Patel, Kaushik
    Stoddart, J. Fraser
    Zink, Jeffrey I.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (12) : 2222 - 2226
  • [4] pH Clock-Operated Mechanized Nanoparticles
    Angelos, Sarah
    Khashab, Niveen M.
    Yang, Ying-Wei
    Trabolsi, Ali
    Khatib, Hussam A.
    Stoddart, J. Fraser
    Zink, Jeffrey I.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (36) : 12912 - +
  • [5] Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]
  • [6] Carbon-Based Nanomaterials: Multifunctional Materials for Biomedical Engineering
    Cha, Chaenyung
    Shin, Su Ryon
    Annabi, Nasim
    Dokmeci, Mehmet R.
    Khademhosseini, Ali
    [J]. ACS NANO, 2013, 7 (04) : 2891 - 2897
  • [7] Chen Y., 2012, Nat. Comm, V3, P1
  • [8] Construction of Homogenous/Heterogeneous Hollow Mesoporous Silica Nanostructures by Silica-Etching Chemistry: Principles, Synthesis, and Applications
    Chen, Yu
    Chen, Hang-Rong
    Shi, Jian-Lin
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2014, 47 (01) : 125 - 137
  • [9] In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles
    Chen, Yu
    Chen, Hangrong
    Shi, Jianlin
    [J]. ADVANCED MATERIALS, 2013, 25 (23) : 3144 - 3176
  • [10] Colloidal HPMO Nanoparticles: Silica-Etching Chemistry Tailoring, Topological Transformation, and Nano-Biomedical Applications
    Chen, Yu
    Xu, Pengfei
    Chen, Hangrong
    Li, Yongsheng
    Bu, Wenbo
    Shu, Zhu
    Li, Yaping
    Zhang, Jiamin
    Zhang, Lingxia
    Pan, Limin
    Cui, Xiangzhi
    Hua, Zile
    Wang, Jin
    Zhang, Linlin
    Shi, Jianlin
    [J]. ADVANCED MATERIALS, 2013, 25 (22) : 3100 - 3105