Gut amyloid-β induces cognitive deficits and Alzheimer's disease-related histopathology in a mouse model

被引:2
|
作者
Vonderwalde, Ilan [1 ]
Finlayson-Trick, Emma [1 ]
机构
[1] Univ British Columbia, Fac Med, Vancouver, BC, Canada
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2021年 / 599卷 / 01期
关键词
Alzheimer's disease; amyloid-beta; central nervous system; gastrointestinal tract; microbiome; mouse model;
D O I
10.1113/JP280624
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:15 / 16
页数:2
相关论文
共 50 条
  • [1] Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
    Spilman, Patricia
    Podlutskaya, Natalia
    Hart, Matthew J.
    Debnath, Jayanta
    Gorostiza, Olivia
    Bredesen, Dale
    Richardson, Arlan
    Strong, Randy
    Galvan, Veronica
    PLOS ONE, 2010, 5 (03):
  • [2] Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease
    Li, Zhuo
    Zhu, Hua
    Guo, Yaxi
    Du, Xiaopeng
    Qin, Chuan
    JOURNAL OF NEUROCHEMISTRY, 2020, 155 (04) : 448 - 461
  • [3] Octovespin, a peptide bioinspired by wasp venom, prevents cognitive deficits induced by amyloid-β in Alzheimer's disease mouse model
    Camargo, Luana Cristina
    Veras, Leticia Germina
    Vaz, Gabriela
    Souza, Adolfo Carlos Barros de
    Mortari, Marcia Renata
    NEUROPEPTIDES, 2022, 93
  • [4] Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer's Disease
    Vyas, Yukti
    Montgomery, Johanna M.
    Cheyne, Juliette E.
    FRONTIERS IN NEUROSCIENCE, 2020, 14
  • [5] Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons
    K Nieweg
    A Andreyeva
    B van Stegen
    G Tanriöver
    K Gottmann
    Cell Death & Disease, 2015, 6 : e1709 - e1709
  • [6] Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons
    Nieweg, K.
    Andreyeva, A.
    van Stegen, B.
    Tanrioever, G.
    Gottmann, K.
    CELL DEATH & DISEASE, 2015, 6 : e1709 - e1709
  • [7] Alzheimer’s disease-related amyloid-β1–42 peptide induces the loss of human sperm function
    R. S. Tavares
    S. Martins
    T. Almeida-Santos
    A. P. Sousa
    J. Ramalho-Santos
    O. A. da Cruz e Silva
    Cell and Tissue Research, 2017, 369 : 647 - 651
  • [8] Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits
    Sagare, Abhay P.
    Sweeney, Melanie D.
    Nelson, Amy R.
    Zhao, Zhen
    Zlokovic, Berislav V.
    TRENDS IN MOLECULAR MEDICINE, 2019, 25 (02) : 74 - 76
  • [9] TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease
    Zhang, Shimeng
    Cao, Feifei
    Li, Wei
    Abumaria, Nashat
    SCIENCE SIGNALING, 2023, 16 (793)
  • [10] Alzheimer's Disease-Related Analytes Amyloid-β and Tau in Perilymph: Correlation With Patient Age and Cognitive Score
    Walia, Amit
    Shew, Matthew A.
    Durakovic, Nedim
    Herzog, Jacques A.
    Cirrito, John R.
    Yuede, Carla M.
    Wick, Cameron C.
    Manis, Melissa
    Holtzman, David M.
    Buchman, Craig A.
    Rutherford, Mark A.
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2024, 171 (06) : 1850 - 1858