Paraoxonase 1 activity in different types of multiple sclerosis

被引：31
作者：
Jamroz-Wisniewska, A. [1 ,2 ]
Beltowski, J. [2 ]
Stelmasiak, Z. [1 ,2 ]
Bartosik-Psujek, H. [1 ,2 ]
机构：
[1] Med Univ Lublin, Dept Neurol, PL-20095 Lublin, Poland
[2] Med Univ Lublin, Dept Pathophysiol, PL-20095 Lublin, Poland
来源：
MULTIPLE SCLEROSIS JOURNAL | 2009年 / 15卷 / 03期
关键词：
arylesterase activity of PON1; multiple sclerosis; paraoxonase; paraoxonase activity of PON1; progressive type of MS; relapsing-remitting type of MS; OXIDATIVE STRESS; PLASMA; SERUM;
D O I：
10.1177/1352458508098371
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background Paraoxonase 1 (PON1) is an antioxidant enzyme bound to plasma high-density lipoproteins and is also present in the brain. Objective The aim of this study was to estimate the activity of PON1 in patients with different types of MS. Methods The PON1 activity toward paraoxon and phenyl acetate and lipid profile was examined in 40 relapsing-remitting (RR) patients in relapse, in 42 RR patients in remission, in 55 progressive MS patients and in 40 healthy individuals. Results PON1 activity did not differ in MS patients compared to control group. PON1 activity in relapse was significantly lower in comparison to the other MS groups. Hypercholesterolemia was observed in MS patients. Conclusion PON1 activity does not change in the course of stable and progressive type of MS and is decreased by the relapse of MS. Multiple Sclerosis 2009; 15: 399-402. http://msj.sagepub.com
引用
收藏
页码：399 / 402
页数：4
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