Paraoxonase 1 activity in different types of multiple sclerosis

被引：30
|
作者：
Jamroz-Wisniewska, A. [1 ,2 ]
Beltowski, J. [2 ]
Stelmasiak, Z. [1 ,2 ]
Bartosik-Psujek, H. [1 ,2 ]
机构：
[1] Med Univ Lublin, Dept Neurol, PL-20095 Lublin, Poland
[2] Med Univ Lublin, Dept Pathophysiol, PL-20095 Lublin, Poland
来源：
MULTIPLE SCLEROSIS JOURNAL | 2009年 / 15卷 / 03期
关键词：
arylesterase activity of PON1; multiple sclerosis; paraoxonase; paraoxonase activity of PON1; progressive type of MS; relapsing-remitting type of MS; OXIDATIVE STRESS; PLASMA; SERUM;
D O I：
10.1177/1352458508098371
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background Paraoxonase 1 (PON1) is an antioxidant enzyme bound to plasma high-density lipoproteins and is also present in the brain. Objective The aim of this study was to estimate the activity of PON1 in patients with different types of MS. Methods The PON1 activity toward paraoxon and phenyl acetate and lipid profile was examined in 40 relapsing-remitting (RR) patients in relapse, in 42 RR patients in remission, in 55 progressive MS patients and in 40 healthy individuals. Results PON1 activity did not differ in MS patients compared to control group. PON1 activity in relapse was significantly lower in comparison to the other MS groups. Hypercholesterolemia was observed in MS patients. Conclusion PON1 activity does not change in the course of stable and progressive type of MS and is decreased by the relapse of MS. Multiple Sclerosis 2009; 15: 399-402. http://msj.sagepub.com
引用
收藏
页码：399 / 402
页数：4
相关论文
共 50 条
  • [1] Paraoxonase 1 Polymorphisms Are Not Related with the Risk for Multiple Sclerosis
    Martinez, Carmen
    Garcia-Martin, Elena
    Benito-Leon, Julian
    Calleja, Patricia
    Diaz-Sanchez, Maria
    Pisa, Diana
    Alonso-Navarro, Hortensia
    Ayuso-Peralta, Lucia
    Torrecilla, Dolores
    Agundez, Jose A. G.
    Javier Jimenez-Jimenez, Felix
    NEUROMOLECULAR MEDICINE, 2010, 12 (03) : 217 - 223
  • [2] Paraoxonase 1 activity and polymorphisms in multiple sclerosis patients
    Durfinova, Monika
    Bartova, Radka
    Prochazkova, Lubica
    Petrlenicova, Darina
    Sykora, Pavel
    Repiska, Vanda
    BIOLOGIA, 2015, 70 (12) : 1672 - 1676
  • [3] Paraoxonase 1 activity in multiple sclerosis patients during mitoxantrone therapy
    Jamroz-Wisniewska, A.
    Beltowski, J.
    Stelmasiak, Z.
    Bartosik-Psujek, H.
    ACTA NEUROLOGICA SCANDINAVICA, 2013, 127 (06): : e33 - e36
  • [4] Paraoxonase 1 activity and polymorphisms in multiple sclerosis patients
    Monika Ďurfinová
    Radka Bartová
    L’ubica Procházková
    Darina Petrleni čová
    Pavel Sýkora
    Vanda Repiská
    Biologia, 2015, 70 : 1672 - 1676
  • [5] Association between serum paraoxonase 1 activity and its polymorphisms with multiple sclerosis: a systematic review
    Salari, Nader
    Rasoulpoor, Shna
    Hosseinian-Far, Amin
    Razazian, Nazanin
    Mansouri, Kamran
    Mohammadi, Masoud
    Vaisi-Raygani, Aliakbar
    Jalali, Rostam
    Shabani, Shervin
    NEUROLOGICAL SCIENCES, 2021, 42 (02) : 491 - 500
  • [6] Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis
    Kirbas, Aynur
    Kirbas, Serkan
    Anlar, Omer
    Efe, Hasan
    Yilmaz, Adnan
    JOURNAL OF CLINICAL NEUROSCIENCE, 2013, 20 (08) : 1106 - 1109
  • [7] Paraoxonase 1 Polymorphisms Are Not Related with the Risk for Multiple Sclerosis
    Carmen Martínez
    Elena García-Martín
    Julián Benito-León
    Patricia Calleja
    María Díaz-Sánchez
    Diana Pisa
    Hortensia Alonso-Navarro
    Lucía Ayuso-Peralta
    Dolores Torrecilla
    José A. G. Agúndez
    Félix Javier Jiménez-Jiménez
    NeuroMolecular Medicine, 2010, 12 : 217 - 223
  • [8] Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity
    Ferretti, G
    Bacchetti, T
    Principi, F
    Di Ludovico, F
    Viti, B
    Angeleri, VA
    Danni, M
    Provinciali, L
    MULTIPLE SCLEROSIS JOURNAL, 2005, 11 (06) : 677 - 682
  • [9] Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population
    Zakrzewska-Pniewska, Beata
    Nojszewska, Monika
    Rog, Teresa
    Pniewski, Jarostaw
    Dorobek, Malgorzata
    Styczynska, Maria
    Szczudlik, Andrzej
    NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2013, 47 (01) : 49 - 52
  • [10] Association between serum paraoxonase 1 activity and its polymorphisms with multiple sclerosis: a systematic review
    Nader Salari
    Shna Rasoulpoor
    Amin Hosseinian-Far
    Nazanin Razazian
    Kamran Mansouri
    Masoud Mohammadi
    Aliakbar Vaisi-Raygani
    Rostam Jalali
    Shervin Shabani
    Neurological Sciences, 2021, 42 : 491 - 500
12345