A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams

被引：91

作者：

Short, KM ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] ONTOGEN CORP,CARLSBAD,CA 92009

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(96)02303-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of small-ring lactams via the condensation ol omega-ketoacids, isocyanides and amines is reported This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product is then released from the support on treatment with 10% TFA/CH2Cl2. Copyright (C) 1996 Elsevier Science Ltd

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页码：359 / 362

页数：4

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