Synthesis of 3-Haloindolizines by Copper(II) Halide Mediated Direct Functionalization of Indolizines

被引：59
|
作者：
Xia, Ji-Bao [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
N-FUSED HETEROCYCLES; POTENT INHIBITORS; QUINOLIZIDINE ALKALOIDS; CATALYZED CYCLOISOMERIZATION; EFFICIENT SYNTHESIS; DERIVATIVES; LIGAND; TETRACHLOROCYCLOPROPENE; 15-LIPOXYGENASE; ARYLATION;
D O I：
10.1021/ol9000872
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizines. This C-H direct functionalization process occurred under mild conditions giving 3-haloindolizines In moderate to excellent yields, and the products obtained were tested under the Suzuki-Miyaura reaction providing 3-arylindolizines in high yields.
引用
收藏
页码：1187 / 1190
页数：4
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