BAG3 is upregulated by c-Jun and stabilizes JunD

被引：27

作者：

Li, Chao ^{[1
,2
,3
]}

Li, Si ^{[4
]}

Kong, De-Hui ^{[1
]}

Meng, Xin ^{[1
]}

Zong, Zhi-Hong ^{[1
]}

Liu, Bao-Qin ^{[1
]}

Guan, Yifu ^{[1
]}

Du, Zhen-Xian ^{[4
]}

Wang, Hua-Qin ^{[1
,2
,3
]}

机构：

[1] China Med Univ, Dept Biochem & Mol Biol, Shenyang 110001, Peoples R China

[2] China Med Univ, Key Lab Med Cell Biol, Minist Educ, Shenyang 110001, Peoples R China

[3] China Med Univ, Key Lab Cell Biol, Minist Publ Hlth, Shenyang 110001, Peoples R China

[4] China Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Shenyang 110001, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2013年 / 1833卷 / 12期

基金：

中国国家自然科学基金;

关键词：

BAG3; c-Jun; Growth inhibition; JunD; PROTEIN-QUALITY CONTROL; CANCER-CELLS; TRANSCRIPTION FACTORS; INDUCED APOPTOSIS; PROSTATE-CANCER; FAMILY PROTEINS; KINASE PATHWAY; EXPRESSION; INHIBITION; GROWTH;

D O I：

10.1016/j.bbamcr.2013.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BAG3 plays a regulatory role in a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, epithelial-mesenchymal transition (EMT), autophagy activation, and virus infection. The AP-1 transcription factors are implicated in a variety of important biological processes including cell differentiation, proliferation, apoptosis and oncogenesis. Recently, it has been reported that AP-1 protein c-Jun inhibits autophagy and enhances apoptotic cell death mediated by starvation. However, the molecular mechanisms remain unclear. For the first time, the current study demonstrated that serum starvation downregulated BAG3 at the transcriptional level via c-Jun. In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by BAG3. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：3346 / 3354

页数：9