Bone tissue engineering: Hope vs hype

被引：404
作者：
Rose, FRAJ
Oreffo, ROC
机构：
[1] Univ Southampton, Gen Hosp, Southampton SO16 6YD, Hants, England
[2] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 292卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
osteoprogenitor; bone marrow; bio-degradable polymer; tissue engineering; scaffold; artificial bone; bone regeneration; stem cell;
D O I：
10.1006/bbrc.2002.6519
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The requirement for new bone to replace or restore the function of traumatised, damaged, or lost bone is a major clinical and socioeconomic need. Bone formation strategies, although attractive, have yet to yield functional and mechanically competent bone. Bone tissue engineering has been heralded as the alternative strategy to regenerate bone. In essence, the discipline aims to combine progenitor or mature cells with biocompatible materials or scaffolds, with or without appropriate growth factors, to initiate repair and regeneration. This brief review outlines the concepts, challenges, and limitations in bone tissue engineering and the potential that could improve the quality of life for many as a result of interdisciplinary collaboration. (C) 2002 Elsevier Science (USA).
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页码：1 / 7
页数：7
相关论文
共 89 条
  • [1] Agrawal CM, 2001, J BIOMED MATER RES, V55, P141, DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.0.CO
  • [2] 2-J
  • [3] Methods for fabricating and characterizing a new generation of biomimetic materials
    Almqvist, N
    Thomson, NH
    Smith, BL
    Stucky, GD
    Morse, DE
    Hansma, PK
    [J]. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 1999, 7 (01): : 37 - 43
  • [4] Andriano KP, 1999, J BIOMED MATER RES, V48, P602, DOI 10.1002/(SICI)1097-4636(1999)48:5<602::AID-JBM3>3.0.CO
  • [5] 2-6
  • [6] ASHTON BA, 1980, CLIN ORTHOP RELAT R, P294
  • [7] Bone marrow stromal stem cells: Nature, biology, and potential applications
    Bianco, P
    Riminucci, M
    Gronthos, S
    Robey, PG
    [J]. STEM CELLS, 2001, 19 (03) : 180 - 192
  • [8] BODEN SD, 1999, CLIN ORTHOP S, V367, pS84
  • [9] Gene-enhanced tissue engineering: Applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene
    Breitbart, AS
    Grande, DA
    Mason, JM
    Barcia, M
    James, T
    Grant, RT
    [J]. ANNALS OF PLASTIC SURGERY, 1999, 42 (05) : 488 - 495
  • [10] Brekke JH, 1998, J BIOMED MATER RES, V43, P380, DOI 10.1002/(SICI)1097-4636(199824)43:4<380::AID-JBM6>3.0.CO
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