Potential of circulating pro-angiogenic microRNA expressions as biomarkers for rapid angiographic stenotic progression and restenosis risks in coronary artery disease patients underwent percutaneous coronary intervention

被引:28
作者
Dai, Rui [1 ]
Liu, Yijue [2 ]
Zhou, Yi [1 ]
Xiong, Xiaoju [1 ]
Zhou, Wei [1 ]
Li, Weijuan [1 ]
Zhou, Wenping [1 ]
Chen, Manhua [1 ]
机构
[1] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Cardiol, 26 Shengli St, Wuhan 430014, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Emergency Dept, Wuhan, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
coronary artery disease; percutaneous coronary intervention; pro-angiogenesis microRNA; rapid angiographic stenotic progression; restenosis; DRUG-ELUTING STENTS; NEOINTIMA FORMATION; CLINICAL-OUTCOMES; BARE-METAL; FOLLOW-UP; REVASCULARIZATION; PROLIFERATION; EPIDEMIOLOGY; IMPLANTATION; ASSOCIATION;
D O I
10.1002/jcla.23013
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background This study aimed to investigate the correlation of pro-angiogenic microRNA (miRNA) expressions with rapid angiographic stenotic progression (RASP) and restenosis risks in coronary artery disease (CAD) patients underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Methods A total of 286 CAD patients underwent PCI with DES were consecutively recruited in this study. Plasma samples were collected before PCI operation, and 14 pro-angiogenic miRNAs were measured by real-time quantitative reverse transcription-polymerase chain reaction. Rapid angiographic stenotic progression at nontarget lesions and restenosis at stented lesions were evaluated by quantitative coronary angiography at 12 months after PCI operation. Results The occurrence rates of RASP and restenosis were 39.5% and 22.4%, respectively. Let-7f, miR-19a, miR-19b-1, miR-92a, miR-126, miR-210, and miR-296 were decreased in RASP patients than non-RASP patients, among which let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlated with lower RASP occurrence by multivariate analysis, followed by receiver-operating characteristic (ROC) curve exhibited that these five miRNAs showed great value in predicting RASP risk with area under curve (AUC) 0.879 (95% CI: 0.841-0.917). Besides, let-7f, miR-19a, miR-92a, miR-126, miR-130a, and miR-210 were reduced in restenosis patients than non-restenosis patients, among them miR-19a, miR-126, miR-210, and miR-378 independently correlated with lower restenosis occurrence by multivariate analysis, followed by ROC curve disclosed that these four miRNAs had good value in predicting restenosis risk with AUC 0.776 (95% CI: 0.722-0.831). Conclusions Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES.
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页数:10
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