Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

被引：7

作者：

Sokolov, V. B. ^{[1
]}

Aksinenko, A. Yu. ^{[1
]}

Goreva, T. V. ^{[1
]}

Epishina, T. A. ^{[1
]}

Dubova, L. G. ^{[1
]}

Dubrovskaya, E. S. ^{[1
]}

Klochkov, S. G. ^{[1
]}

Shevtsov, P. N. ^{[1
]}

Shevtsova, E. F. ^{[1
]}

Bachurin, S. O. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiologically Act Subst, 1 Severnyi Proezd, Chernogolovka 142432, Moscow Region, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2016年 / 65卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

carbazoles; tetrahydrocarbazoles; 3,6-substituted 9-oxiranylmethylcarbazoles; 2,8-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles; 1-(9H-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)propan-2-ones; catalytic alkylation; mitochondria; neuroprotection; mitochondrial permeability transition; tubulin; glutamate toxicity; DERIVATIVES; MICE;

D O I：

10.1007/s11172-016-1582-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9De-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5De-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.

引用

页码：2306 / 2311

页数：6

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