Immune Priming of the Tumor Microenvironment by Radiation

被引：138

作者：

Jiang, Wen ^{[1
]}

Chan, Charles K. ^{[2
]}

Weissman, Irving L. ^{[2
]}

Kim, Betty Y. S. ^{[3
,4
,5
]}

Hahn, Stephen M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[2] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[3] Mayo Clin Florida, Dept Canc Biol, Jacksonville, FL 32224 USA

[4] Mayo Clin Florida, Dept Neurosci, Jacksonville, FL 32224 USA

[5] Mayo Clin Florida, Dept Neurosurg, Jacksonville, FL 32224 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 11期

关键词：

IMMUNOGENIC CELL-DEATH; TGF-BETA; T-CELLS; CANCER; EXPRESSION; BLOCKADE; RADIOTHERAPY; MECHANISMS; RESPONSES; HYPOXIA;

D O I：

10.1016/j.trecan.2016.09.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic changes in both normal stromal and cancer cells, leading to molecular and physiological alterations within the tumor microenvironment. These environmental modulations directly influence the degree of immunogenicity of the tumor microenvironment and may ultimately affect tumor responsiveness to cancer immunotherapies. Here we review the preclinical evidence for tumor microenvironment-mediated immune suppression and how radiation can modulate immune properties within a tumor. We then discuss the therapeutic opportunities for combining radiation with molecular agents to enhance tumor immunogenicity and how this represents a potential exciting strategy to complement immunotherapies including immune checkpoint blockers in cancer treatment.

引用

页码：638 / 645

页数：8

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