Enantioselective synthesis of isoquinoline-1,3(2H,4H)-dione derivatives via a chiral phosphoric acid catalyzed aza-Friedel-Crafts reaction

被引：27

作者：

You, Yong ^{[1
]}

Lu, Wen-Ya ^{[2
]}

Xie, Ke-Xin ^{[3
]}

Zhao, Jian-Qiang ^{[1
]}

Wang, Zhen-Hua ^{[1
]}

Yuan, Wei-Cheng ^{[1
,2
]}

机构：

[1] Chengdu Univ, Inst Far Adv Study, Chengdu 610106, Sichuan, Peoples R China

[2] Chinese Acad Sci, Natl Engn Res Ctr Chiral Drugs, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 58期

关键词：

ASYMMETRIC-SYNTHESIS; INDOLES; ISATINS; ALKENES;

D O I：

10.1039/c9cc04057a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective aza-Friedel-Crafts reaction of structurally new ketimines with indoles and pyrrole is developed by using a chiral phosphoric acid as the catalyst. This protocol enables the first enantioselective synthesis of isoquinoline-1,3(2H,4H)-dione derivatives in good to excellent yields (up to 99% yield) and excellent enantioselectivities (up to >99% ee).

引用

页码：8478 / 8481

页数：4

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