Non-professional phagocytosis: a general feature of normal tissue cells

被引：48

作者：

Seeberg, Jacob C. ^{[1
]}

Loibl, Monika ^{[1
]}

Moser, Fabian ^{[1
]}

Schwegler, Manuela ^{[1
]}

Buettner-Herold, Maike ^{[2
]}

Daniel, Christoph ^{[2
]}

Engel, Felix B. ^{[2
]}

Hartmann, Arndt ^{[3
]}

Schloetzer-Schrehardt, Ursula ^{[4
]}

Goppelt-Struebe, Margarete ^{[5
]}

Schellerer, Vera ^{[6
]}

Naschberger, Elisabeth ^{[6
]}

Ganzleben, Ingo ^{[7
]}

Heinzerling, Lucie ^{[8
]}

Fietkau, Rainer ^{[1
]}

Distel, Luitpold, V ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Radiat Oncol, D-91054 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg, Dept Nephropathol, Expt Renal & Cardiovasc Res, D-91054 Erlangen, Germany

[3] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Pathol, D-91054 Erlangen, Germany

[4] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, D-91054 Erlangen, Germany

[5] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Med Nephrol & Hypertens 4, D-91054 Erlangen, Germany

[6] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Surg, D-91054 Erlangen, Germany

[7] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Med 1, D-91054 Erlangen, Germany

[8] Friedrich Alexander Univ Erlangen Nurnberg, Univ Clin Erlangen, Dept Dermatol, D-91054 Erlangen, Germany

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

关键词：

CILIARY EPITHELIAL-CELLS; DEATH PROCESS; CANNIBALISM; TRANSFORMATION; CLEARANCE; CARCINOMA; ENTOSIS; SYSTEM; SV40; EYE;

D O I：

10.1038/s41598-019-48370-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Non-professional phagocytosis by cancer cells has been described for decades. Recently, non-professional phagocytosis by normal tissue cells has been reported, which prompted us to take a closer look at this phenomenon. Non-professional phagocytosis was studied by staining cultured cells with live-cell staining dyes or by staining paraffin-embedded tissues by immunohistochemistry. Here, we report that each of 21 normal tissue cell lines from seven different organs was capable of phagocytosis, including ex vivo cell cultures examined before the 3rd passage as well as the primary and virus-transformed cell lines. We extended our analysis to an in vivo setting, and we found the occurrence of non-professional phagocytosis in healthy skin biopsies immediately after resection. Using dystrophin immunohistochemistry for membrane staining, human post-infarction myocardial tissue was assessed. We found prominent signs of non-professional phagocytosis at the transition zone of healthy and infarcted myocardia. Taken together, our findings suggest that non-professional phagocytosis is a general feature of normal tissue cells.

引用

页数：8

共 34 条

[1] Cell cannibalism in ductal carcinoma of breast [J].