Cerebrospinal fluid biomarkers in multiple sclerosis

被引：89
作者：
Tumani, Hayrettin [1 ]
Hartung, Hans-Peter [2 ]
Hemmer, Bernhard [3 ]
Teunissen, Charlotte [4 ]
Deisenhammer, Florian [5 ]
Giovannoni, Gavin [6 ]
Zettl, Uwe K. [7 ]
机构：
[1] Univ Ulm, Dept Neurol, D-89081 Ulm, Germany
[2] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
[3] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany
[4] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands
[5] Innsbruck Med Univ, Dept Clin Neurol, A-6020 Innsbruck, Austria
[6] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, Neuroimmunol Unit, Ctr Neurosci, London E1 2AT, England
[7] Univ Rostock, Dept Neurol, D-18147 Rostock, Germany
来源：
NEUROBIOLOGY OF DISEASE | 2009年 / 35卷 / 02期
关键词：
Multiple sclerosis; Clinically isolated syndrome; Cerebrospinal fluid; Biomarker; Demyelination; Remyelination; Axonal damage; Glial activation; Blood-brain barrier; Blood-CSF barrier; MYELIN BASIC-PROTEIN; MESSENGER-RNA EXPRESSION; NERVE-FIBER LAYER; CLINICALLY ISOLATED SYNDROMES; SOLUBLE ADHESION MOLECULES; NITRIC-OXIDE METABOLITES; FIBRILLARY ACIDIC PROTEIN; INTRATHECAL IGM-SYNTHESIS; PRIMARY PROGRESSIVE MS; NECROSIS-FACTOR-ALPHA;
D O I：
10.1016/j.nbd.2009.04.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：117 / 127
页数：11
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