Total synthesis of pseudolaric acid A

被引：71
作者：
Geng, Zhe
Chen, Bin
Chiu, Pauline
机构：
[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 37期
关键词：
antitumor agents; carbenoids; domino reactions; natural products; total synthesis;
D O I：
10.1002/anie.200602056
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) The antiangiogenic and cytotoxic natural product pseudolaric acid A ((-)-1) has been obtained by a 26-step synthetic route. This enantioselective synthesis employed an intramolecular carbene cyclization cycloaddition cascade reaction as the key step to construct the carbocyclic framework. PMB = para-methoxybenzyl. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6197 / 6201
页数：5
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