Effects of electroconvulsive seizures on Na+,K+-ATPase activity in the rat hippocampus

被引：15

作者：

Streck, Emilio L. ^{[1
]}

Feier, Gustavo

Burigo, Marcio

Franzon, Renata

Dal-Pizzol, Felipe

Quevedo, Joao

Wyse, Angela T. S.

机构：

[1] Univ Extremo Sul Catarinense, Lab Bioquim Expt, BR-99906000 Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Lab Neurociencias, BR-99906000 Criciuma, SC, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Lab Erros Inatos Metab, BR-90035003 Porto Alegre, RS, Brazil

[4] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, BR-99906000 Criciuma, SC, Brazil

来源：

NEUROSCIENCE LETTERS | 2006年 / 404卷 / 03期

关键词：

electroconvulsive shock; electroconvulsive therapy; Na+; K+-ATPase; hippocampus;

D O I：

10.1016/j.neulet.2006.06.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na+,K+-ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40-50% of brain ATR This work was performed in order to determine Na+,K+-ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na+,K+-ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na+,K+-ATPase activity is altered by ECS. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：254 / 257

页数：4

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